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製品番号: HY-19480B

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Ulodesine succinate

Name: Ulodesine succinate
Brand: MedChemExpress
SKU: HY-19480B
Availability: PreOrder

(別名: BCX4208 succinate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Ulodesine succinate (BCX4208 succinate) is a purine nucleoside phosphorylase (PNP) inhibitor, with an IC₅₀ of 2.293 nM against human PNP, and low nanomolar IC₅₀ values against mouse, rat and monkey PNP. Ulodesine succinate blocks the production of uric acid precursors, reduces serum uric acid levels, clears accumulated uric acid in the blood, and elevates the levels of purine nucleosides including guanosine. Ulodesine succinate reduces the counts of total lymphocytes, T lymphocytes and lymphocyte subsets, inhibits the proliferation of cancer cells and activated lymphocytes, and enhances vaccine immune responses. Ulodesine succinate can be used in research related to hyperuricemia and gout.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1246200-39-4
分子式: C₁₂H₁₆N₄O₃·1/2C₄H₆O₄
分子量:323.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Ulodesine succinate 構造式

CAS 番号: 1246200-39-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
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Publications (1)
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生物活性

製品説明

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]

PNP

2.293 nM (IC₅₀)

体外実験

OthersAnti-cancerNucleotide Metabolism

Others

Ulodesine succinate exhibits potent nanomolar-range inhibitory activity against PNP, with an IC₅₀ of 2.293 nmol/L^[1].

Anti-cancer

Nucleotide Metabolism

Ulodesine succinate (low nM) potently inhibits PNP and blocks proliferation of T-ALL cell lines at low nM concentrations, inhibits activated normal PBLs with lower potency, and has no effect on HUT102 CTCL cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Nucleotide Metabolism

Ulodesine (i.v.) succinate significantly reduces elevated blood uric acid levels and eliminates urate accumulation in hyperuricemic model mice after intravenous administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

化学情報

CAS 番号 1246200-39-4
分子量 323.33
分子式 C₁₂H₁₆N₄O₃·1/2C₄H₆O₄
SMILES

OC(CCC(O)=O)=O.O=C(N=CN1)C2=C1C(CN3C[C@@H]([C@H](C3)O)CO)=CN2.[1/2]
別名

BCX4208 succinate
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Gut Microbes

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [Abstract]

2026 Dec 31;18(1):2620124. PMID: 41605881

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]

[2]. Shahid H, et al. Investigational drugs for hyperuricemia. Expert opinion on investigational drugs. 2015;24(8):1013-30. [Content Brief]

[3]. Bantia S. Purine Nucleoside Phosphorylase Inhibitors as Novel Immuno-Oncology Agent and Vaccine Adjuvant. Int J Immunol Immunother. 2020;7:043.

[4]. Tang DH, et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol. 2021 Dec;59(1):175-182. [Content Brief]

[5]. Evans GB, et al. Immucillins in Infectious Diseases. ACS infectious diseases. 2018 Feb 09;4(2):107-117. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ulodesine succinate

1 Cited Publications

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Ulodesine succinate

MedChemExpress（MCE）の使用を引用している文献 Ulodesine succinate

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Ulodesine succinate

MedChemExpress（MCE）の使用を引用している文献 Ulodesine succinate

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