UR-PI376
UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC50 value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R.
For research use only. We do not sell to patients.
- CAS No.: 1192559-94-6
- Formula: C17H22N6S
- Molecular Weight:342.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histamine Receptor Isoforms
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Biological Activity
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Human H4 Receptor 7.47 (pEC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | EC50 |
37 nM
Compound: 1; UR-PI376
|
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
|
[PMID: 27007611] |
| Sf9 | EC50 |
720 nM
Compound: 1; UR-PI376
|
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
|
[PMID: 27007611] |
Chemical Information
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CAS No. 1192559-94-6
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Molecular Weight 342.46
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Formula C17H22N6S
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SMILES
N#CN/C(NCCSC1=CC=CC=C1)=N\CCCCC2=CN=CN2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)