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Cat. No.: HY-121002

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Alstonine

Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.

For research use only. We do not sell to patients.

CAS No.: 642-18-2
Formula: C₂₁H₂₀N₂O₃
Molecular Weight:348.40

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Alstonine Chemical Structure

CAS No.: 642-18-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties^[1].

IC₅₀ & Target

Plasmodium

All Parasite Isoforms :

In Vitro

Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg^[1].
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages^[1].
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 642-18-2
Appearance Solid
Molecular Weight 348.40
Formula C₂₁H₂₀N₂O₃
Color White to yellow
SMILES

COC(C1=CO[C@H]([C@]2([C@@]1(CC3=[N+](C=CC4=C3[N-]C5=C4C=CC=C5)C2)[H])[H])C)=O
Structure Classification
- Alkaloids
- Pyridine Alkaloids
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. E Elisabetsky, et al. The Alkaloid Alstonine: A Review of Its Pharmacological Properties. Evid Based Complement Alternat Med. 2006 Mar;3(1):39-48. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Alstonine

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Alstonine Related Classifications

HY-121002 Related Classifications