PDGFRA - platelet derived growth factor receptor alpha Gene

Also Known as CD140A; PDGFR2; PDGFR-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5156

About PDGFRA

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:54,229,293-54,298,245 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 134 phenotypes. Ubiquitous expression in ovary (RPKM 74.4), brain (RPKM 24.8) and 20 other tissues.

Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of Other cancers. [provided by RefSeq, Mar 2012]

PDGFRA Products (10)

mRNA	Protein	Name
NM_006206.6	NP_006197.1	platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347829.2	NP_001334758.1	platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347828.2	NP_001334757.1	platelet-derived growth factor receptor alpha isoform 3
XM_047415766.1	XP_047271722.1	platelet-derived growth factor receptor alpha isoform X1
XM_017008281.2	XP_016863770.1	platelet-derived growth factor receptor alpha isoform X3
NM_001347827.2	NP_001334756.1	platelet-derived growth factor receptor alpha isoform 2 precursor
XM_005265743.2	XP_005265800.1	platelet-derived growth factor receptor alpha isoform X1
NM_001347830.2	NP_001334759.1	platelet-derived growth factor receptor alpha isoform 4
XM_047415767.1	XP_047271723.1	platelet-derived growth factor receptor alpha isoform X1
XM_006714041.4	XP_006714104.1	platelet-derived growth factor receptor alpha isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase C activator activity	IMP IMP: Inferred from mutant phenotype	1646396	GOA
enables platelet-derived growth factor alpha-receptor activity	IDA IDA: Inferred from direct assay	2536956	GOA
enables platelet-derived growth factor alpha-receptor activity	IMP IMP: Inferred from mutant phenotype	2554309	GOA
enables platelet-derived growth factor binding	IDA IDA: Inferred from direct assay	2554309	GOA
enables platelet-derived growth factor binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	2542288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7679113	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2542288	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	24190966	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	1646396	GOA
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	17470632	GOA
enables vascular endothelial growth factor receptor activity	IDA IDA: Inferred from direct assay	17470632	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	24190966	GOA
involved in negative regulation of platelet activation	IDA IDA: Inferred from direct assay	8188664	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	2536956	GOA
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	8188664	GOA
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	2536956	GOA
involved in platelet-derived growth factor receptor-alpha signaling pathway	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	10734113	GOA
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	17470632	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	1646396	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10806482	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17470632	GOA
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	10806482	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	2536956	GOA
involved in regulation of mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	21596750	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	2536956	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24190966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFRA Protein Structure

Ig_2

I-set

Pkinase_Tyr

0
200
400
600
800
1000
1089 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor alpha	CD140 antigen-like family member A CD140a antigen PDGF-R-alpha alpha-type platelet-derived growth factor receptor platelet-derived growth factor receptor 2 platelet-derived growth factor receptor, alpha polypeptide

PDGFRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDGFRA	P16234	PDGFB	Homo sapiens	P01127	Competition Binding	7679113
Intra	PDGFRA	P16234	PDGFB	Homo sapiens	P01127	ELISA	7679113
Intra	PDGFRA	P16234	PDGFB	Homo sapiens	P01127	Competition Binding	10806482
Intra	PDGFRA	P16234	PDGFA	Homo sapiens	P04085	Competition Binding	7679113
Intra	PDGFRA	P16234	PDGFA	Homo sapiens	P04085	ELISA	7679113
Intra	PDGFRA	P16234	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	PDGFRA	P16234	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PDGFRA	P16234	SFN	Homo sapiens	P31947	Crosslink	36931259
Intra	PDGFRA	P16234	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	PDGFRA	P16234	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
Intra	PDGFRA	P16234	PDGFC	Homo sapiens	Q9NRA1	Competition Binding	10806482
Intra	PDGFRA	P16234	PDGFC	Homo sapiens	Q9NRA1	Affinity Chrom	35384245
Intra	PDGFRA	P16234	CRK	Homo sapiens	P46108	CoIP	9546424
Intra	PDGFRA	P16234	CRK	Homo sapiens	P46108	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDGFRA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72495	PDGFRA Protein, Human (HEK293, His)	P16234-1 (Q24-E524)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73356	PDGFRA Protein, Human (HEK293, Fc)	P16234-1/NP_006197.1 (Q24-E524)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78193	PDGF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	P16234-1 (Q24-E524)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78506	PDGF R alpha Protein, Human (HEK293, His-Avi)	P16234-1 (Q24-E524)	≥ 95%, as determined by Bis-Tris PAGE.

PDGFRA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80510	PDGFR alpha Antibody (YA239)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P84127	PDGFR alpha Antibody (YA3824)	ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84127A	PDGFR alpha Antibody (YA3824)(PBS only)	ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84128	PDGFR alpha Antibody (YA3825)	IHC-P, FC, ELISA	Human
HY-P84128A	PDGFR alpha Antibody (YA3825)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86319	PDGFR alpha Antibody (YA6011)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86661	PDGFR alpha Antibody (YA6353)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Leiomyosarcoma	Leiomyosarcomas
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Brain Glioma	Lower Grade Glioma Intracranial Glioma Glioma Nos
Gist-Plus Syndrome	Polyps, Multiple And Recurrent Inflammatory Fibroid, Gastrointestinal GISTPS Gastrointestinal Stromal Tumor/Gist-Plus Syndrome, Somatic Or Familial Polyps, Multiple And Recurrent Inflammatory Fibroid, Gastrointestinal, Formerly Gastrointestinal Stromal Tumor/Gist-Plus Syndrome
Jejunal Neoplasm	Jejunal Tumor Neoplasm Of Jejunum Tumor Of Jejunum
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Small Intestinal Sarcoma	Sarcoma Of The Small Intestine
Gastric Leiomyosarcoma	Leiomyosarcoma Of Stomach
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Gastric Liposarcoma	Liposarcoma Of The Stomach
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Budd-Chiari Syndrome	Hepatic Vein Thrombosis BDCHS Membranous Obstruction Of The Inferior Vena Cava Chiari Syndrome Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Plexiform Neurofibroma	Neurofibroma Plexiform Neurofibroma, Plexiform
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Cervical Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Cervix Adenosquamous Cell Carcinoma Of The Cervix Uteri
Hemangioblastoma	Capillary Hemangioblastoma
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Pdgfra, Pdgfrb, And Fgfr1	Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , And Fibroblast Growth Factor Receptor-1 Are A Group Of Hematologic Neoplasms Myeloid And Lymphoid Neoplasms With Eosinophilia And Rearrangement Of Pdgfra, Pdgfrb, Or Fgfr1, Or With Pcm1-Jak2
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Astigmatism
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Heart Leiomyosarcoma	Leiomyosarcoma Of Heart Cardiac Leiomyosarcoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Familiar Ovarian Carcinoma
Chronic Eosinophilic Pneumonia	Carrington Syndrome Idiopathic Chronic Eosinophilic Pneumonia Cryptogenic Pulmonary Eosinophilia Idiopathic Eosinophilic Chronic Pneumopathy Carrington'S Disease Carrington'S Pulmonary Eosinophilia Chronic Idiopathic Eosinophilic Pneumonia Eosinophilic Idiopathic Chronic Pneumopathy Eosinophilic Pneumonia Chronic
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Loeffler Endocarditis	Eosinophilic Endomyocardial Disease Eosinophilic Endocarditis Loeffler'S Endocarditis Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy
Primary Hypereosinophilic Syndrome	Clonal Hypereosinophilic Syndrome Hes-M Hes-N Neoplastic Hypereosinophilic Syndrome Primary Hes Hm Syndrome
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Disseminated Eosinophilic Collagen Disease
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Idh-Mutant Glioblastoma
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Sm-Ahnmd	Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease
Retinal Melanoma	Malignant Retinal Melanoma Malignant Melanoma Of Retina
Mastocytosis, Cutaneous	Urticaria Pigmentosa Cutaneous Mastocytosis Diffuse Cutaneous Mastocytosis Maculopapular Cutaneous Mastocytosis Mastocytosis, Diffuse Cutaneous MASTC Mastocytosis, Maculopapular Cutaneous Mastocytosis, Systemic, Somatic Mastocytoma Dcm Diffuse Cutaneous Maculopapulous Mastocytosis Up/Mpcm Cm Mastocytosis, Systemic MASTSYS Mast Cell Disease Mast-Cell Disease Mast Cell Leukemia Mastocytosis, Indolent Mastocytosis With Associated Hematologic Disorder Mast Cell Neoplasm Benign Mastocytoma
Stress Polycythemia	Gaisbock'S Syndrome Polycythemia, Emotional Pseudopolycythaemia Gaisboeck'S Syndrome Pseudopolycythemia Gaisbock Syndrome Stress Erythrocytosis Pseudo-Polycythemia Relative Erythrocytosis
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Ciliary Dyskinesia, Primary, 20	Primary Ciliary Dyskinesia 20 CILD20 Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus Ics20 Immotile Cilia Syndrome 20 Dyskinesia, Ciliary, Primary, 20
Piebald Trait	Piebaldism PBT Partial Albinism Albinoidism, Oculocutaneous, Autosomal Dominant
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Ciliary Dyskinesia, Primary, 30	Primary Ciliary Dyskinesia 30 CILD30 Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus Primary Ciliary Dyskinesia 30 Without Situs Inversus Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 30
Carney Triad	Gastric Leiomyosarcoma, Pulmonary Chondroma, And Extraadrenal Paraganglioma
Rhabdomyosarcoma
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Brain Stem Cancer	Brain Stem Neoplasms Malignant Neoplasm Of Brain Stem Malignant Neoplasm Of Brainstem Neoplasm Of Adult Brain Stem Neoplasm Of Brain Stem Primary Brain Stem Neoplasm Primary Brain Stem Tumor Brain Stem Neoplasm Brain Stem--Cancer Brain Stem Neoplasms, Primary
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukaemia Atypical Chronic Myeloid Leukemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Hypereosinophilic Syndrome, Idiopathic	Idiopathic Hypereosinophilic Syndrome Hypereosinophilic Syndrome, Idiopathic, Resistant To Imatinib HES
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Anaplastic Oligodendroglioma
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Endometrial Small Cell Carcinoma
Angiosarcoma	Hemangiosarcoma
Conventional Fibrosarcoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Low Grade Glioma	Benign Glioma
Indolent Systemic Mastocytosis	Ism
Liposarcoma	Lipomatous Cancer
Ureter Small Cell Carcinoma	Ureteral Small Cell Carcinoma
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic/Myeloproliferative Disease Myelodysplastic-Myeloproliferative Diseases Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Diffuse Astrocytoma	Diffuse Astrocytoma, Low Grade Who Grade Ii Astrocytoma Fibrillary Astrocytoma Gemistocytic Astrocytoma Low-Grade Diffuse Astrocytoma Protoplasmic Astrocytoma
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Chronic Neutrophilic Leukemia	Cnl Leukemia Neutrophilic Chronic
Histone Mutated Tumor	Histone Mutated Tumour
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Deep Leiomyoma
Idh-Wildtype Glioblastoma
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Chondroma	Central Chondroma Enchondroma
Small Intestine Leiomyoma	Leiomyoma, Small Bowel Leiomyoma Of Small Intestine
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Mixed Glioma	Mixed Gliomas Mixed Neuroglial Tumor Glioma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Malignant Peripheral Nerve Sheath Tumor	Mpnst Malignant Neurilemmoma Neurofibrosarcoma Malignant Neurofibroma Malignant Schwannoma Neurogenic Sarcoma Malignant Neoplasm Of The Peripheral Nerve Sheath Schwannoma, Malignant Malignant Peripheral Nerve Sheath Tumors
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13001	Quizartinib		99.08%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Unkown
HY-13001R	Quizartinib (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10254	PDGFRA Human Pre-designed siRNA Set A		/	Unkown
HY-108444	(Z)-FeCP-oxindole	Inhibitor	99.62%	Unkown
HY-13001S	Quizartinib-d8		/	Unkown
HY-108444A	(E)-FeCP-oxindole	Inhibitor	/	Unkown
HY-149510	MET/PDGFRA-IN-1		/	Unkown
HY-149511	MET/PDGFRA-IN-2		/	Unkown
HY-170911	KIT/PDGFRA-IN-1	Inhibitor	/	Unkown
HY-173124	CDK2/FLT4/PDGFRA-IN-1		/	Unkown
HY-175212	PDGFRA-IN-1	Inhibitor	/	Unkown
HY-181108	GSK190937	Inhibitor	/	Unkown
HY-181587	PDGFRA/CAIX/XII-IN-1		98.10%	Unkown
HY-181886	AK177		/	Unkown
HY-RS10255	Pdgfra Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10256	PDGFRA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174549	Human PDGFRA mRNA		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDGFRA	VGNC	VGNC:44372
Felis catus	PDGFRA	VGNC	VGNC:78545
Rattus norvegicus	PDGFRA	RGD	RGD:3284
Bos taurus	PDGFRA	VGNC	VGNC:32692
Mus musculus	PDGFRA	MGD	MGI:97530
Others	PDGFRA	NCBI