CD63 - CD63 molecule Gene

Also Known as MLA1; ME491; LAMP-3; OMA81H; TSPAN30

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 967

About CD63

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,725,323-55,729,673 (from NCBI)

This gene has 16 transcripts (splice variants), 207 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 184.8), colon (RPKM 181.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

CD63 Products (16)

mRNA	Protein	Name
NM_001257389.2	NP_001244318.1	CD63 antigen isoform A
NM_001257390.2	NP_001244319.1	CD63 antigen isoform A
NM_001257391.2	NP_001244320.1	CD63 antigen isoform A
NM_001257392.1	NP_001244321.1	CD63 antigen isoform C
NM_001257400.2	NP_001244329.1	CD63 antigen isoform D precursor
NM_001257401.2	NP_001244330.1	CD63 antigen isoform D precursor
NM_001267698.2	NP_001254627.1	CD63 antigen isoform A
NM_001413281.1	NP_001400210.1	CD63 antigen isoform A
NM_001413282.1	NP_001400211.1	CD63 antigen isoform A
NM_001413283.1	NP_001400212.1	CD63 antigen isoform A
NM_001413284.1	NP_001400213.1	CD63 antigen isoform A
NM_001413285.1	NP_001400214.1	CD63 antigen isoform A
NM_001413286.1	NP_001400215.1	CD63 antigen isoform D precursor
NM_001413287.1	NP_001400216.1	CD63 antigen isoform E
NM_001413288.1	NP_001400217.1	CD63 antigen isoform F
NM_001780.6	NP_001771.1	CD63 antigen isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16917503	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	23632027	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	23632027	GOA
involved in endosome to melanosome transport	IMP IMP: Inferred from mutant phenotype	21962903	GOA
involved in pigment granule maturation	IMP IMP: Inferred from mutant phenotype	21962903	GOA
involved in positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16917503	GOA
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	23632027	GOA
acts upstream of or within regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	15647390	GOA
involved in regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	23632027	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15647390	GOA
located in endosome lumen	IDA IDA: Inferred from direct assay	22660413	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15229288	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15908444	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	23632027	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	22431521	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	26280656	GOA
located in multivesicular body, internal vesicle	IDA IDA: Inferred from direct assay	21962903	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16917503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD63 Protein Structure

Tetraspannin

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
CD63 antigen	CD63 antigen (melanoma 1 antigen)

CD63 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD63	P08962	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	CD63	P08962	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	CD63	P08962	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	CD63	P08962	TIMP1	Homo sapiens	P01033	Anti Bait CoIP	16917503
Cross	CD63	P08962	P04578-PRO_0000038428	Human immunodeficiency virus	P04578-PRO_0000038428	PLA	25312088

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD63 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72715	CD63 Protein, Human/Cynomolgus (HEK293, N-His)	P08962-1/NP_001253224 (A103-V203)	≥ 95%, as determined by reducing SDS-PAGE.

CD63 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80604	CD63 Antibody (YA530)	WB, IHC-P	Mouse
HY-P80604A	CD63 Antibody (YA530)(PBS only)	WB, IHC-P, ICC/IF	Mouse
HY-P85002	CD63 Antibody (YA4694)	ELISA	Human
HY-P85885	CD63 Antibody (YA5577)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P85885A	CD63 Antibody (YA5577)(PBS only)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
HY-P85952	CD63 Antibody (YA5644)	IHC-P, WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Storage Pool Platelet Disease	Platelet Storage Pool Deficiency Storage Pool Disease Of Platelets Dense Body Defect Platelet Dense Granule Deficiency Platelet Storage Pool Defect Platelet Storage Pool Diseases Alpha Delta Granule Deficiency Alpha Dense Granule Deficiency Combined Alpha-Delta Platelet Storage Pool Deficiency
Chediak-Higashi Syndrome	CHS Chédiak-Higashi Syndrome Chediak - Steinbrinck Anomaly Chediak Higashi Syndrome Chediak-Steinbrinck-Higashi Syndrome Oculocutaneous Albinism With Leukocyte Defect Chediak-Higashi Disease Chediak-Higashi-Steinbrink Syndrome
Diclofenac Allergy	Voltaren Allergy
Oculocutaneous Albinism	Albinism, Oculocutaneous Oca Albinism Oculocutaneous Oca - [Oculocutaneous Albinism]
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Amoxicillin Allergy
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Quebec Platelet Disorder	Factor V Quebec QPD Bdplt5 Bleeding Disorder, Platelet-Type, 5 Platelet-Type Bleeding Disorder 5 Bleeding Disorder Platelet-Type 5 Platelet Disorder, Quebec
Rocuronium Allergy	Esmeron Allergy Zemuron Allergy
Congenital Myasthenic Syndrome 7	Cms7 Congenital Myasthenic Syndrome 7 Presynaptic Myasthenic Syndrome, Congenital, Type 7, Presynaptic
Diphtheria	Corynebacterium Infections Corynebacterium Infection Diphtherial Infection Infection Due To Corynebacterium Diphtheriae
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Cefaclor Allergy	Ceclor Allergy Cephaclor Allergy
Beta-Lactam Allergy
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Drug Allergy	Allergy Drug Drug Allergies
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Chlorhexidine Allergy
Cephalosporin Allergy
Nut Allergy	Nut Allergic Reaction Nut Hypersensitivity Allergy To Nuts Allergy Nut
Dermatographia	Dermatographic Urticaria Dermographism Symptomatic Dermographism Urticaria Factitia Factitious Urticaria Dermatographism
Fruit Allergy	Allergy To Fruit
Peach Allergy	Prunus Persica Fruit Allergy
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Legume Allergy	Fabaceae Allergy
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Arteriosclerosis	Arteriosclerotic Vascular Disease
Peanut Allergy	Allergy To Peanuts Peanut Allergic Reaction Allergies Peanut Peanut Hypersensitivity
Latex Allergy
Physical Urticaria	Symptomatic Dermographism
Pollen Allergy	Hay Fever
Oxirane Allergy	Ethylene Oxide Allergy Eto Allergy
Ceftazidime Allergy	Fortaz Allergy Tazicef Allergy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Corneal Dystrophy, Posterior Polymorphous, 2	Posterior Polymorphous Corneal Dystrophy 2 PPCD2 Corneal Dystrophy, Posterior Polymorphous 2 Corneal Dystrophy Polymorphous Posterior, 2 Dystrophy, Corneal, Posterior Polymorphous, Type 2
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11174	CP05	Ligand	97.10%	Unkown
HY-P11797	EP9		99.84%	Unkown
HY-RS02260	CD63 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-146332	Collagen-IN-1	Inhibitor	/	Unkown
HY-146333	TRAP-6-IN-1	Inhibitor	/	Unkown
HY-182080	EVs inducer-1	Inhibitor	/	Unkown
HY-182081	Tubulin polymerization-IN-90		/	Unkown
HY-185600	CD63 aptamer sodium		/	Unkown
HY-RS16762	Cd63 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23201	Cd63 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991929	Anti-CD63 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD63	RGD	RGD:62080
Mus musculus	CD63	MGD	MGI:99529
Macaca mulatta	CD63	VGNC	VGNC:70775
Felis catus	CD63	VGNC	VGNC:83518
Canis familiaris	CD63	VGNC	VGNC:38967
Others	CD63	NCBI