Vindesine
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 53643-48-4
- Formula: C43H55N5O7
- Molecular Weight:753.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Vindesine binds to intracellular tubulin, thereby inhibiting the assembly of functional microtubules in actively dividing cells[2].
Vindesine potently inhibits mitosis in cancer cell lines[3].
Vindesine inhibits the invasion of malignant cells into normal tissues in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53643-48-4
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Molecular Weight 753.93
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Formula C43H55N5O7
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SMILES
CN([C@]1([H])[C@@]23[C@]4([H])[C@](C=CCN4CC3)(CC)[C@@H](O)[C@]1(O)C(N)=O)C(C2=C5)=CC(OC)=C5[C@](C[C@]6([H])C[N@]7C[C@@](CC)(O)C6)(C(OC)=O)C8=C(CC7)C9=CC=CC=C9N8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (132.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Gökbuget N, et al. Vindesine in the treatment of leukaemia. Leuk Lymphoma. 1997;26(5-6):497-506. [Content Brief]
[2]. Sørensen JB, et al. Is there a role for vindesine in the treatment of non-small cell lung cancer?. Invest New Drugs. 1993;11(2-3):103-133. [Content Brief]
[3]. Dhyani P, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):206. Published 2022 Jun 2. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3264 mL | 6.6319 mL | 13.2638 mL | 33.1596 mL |
| 5 mM | 0.2653 mL | 1.3264 mL | 2.6528 mL | 6.6319 mL | |
| 10 mM | 0.1326 mL | 0.6632 mL | 1.3264 mL | 3.3160 mL | |
| 15 mM | 0.0884 mL | 0.4421 mL | 0.8843 mL | 2.2106 mL | |
| 20 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6580 mL | |
| 25 mM | 0.0531 mL | 0.2653 mL | 0.5306 mL | 1.3264 mL | |
| 30 mM | 0.0442 mL | 0.2211 mL | 0.4421 mL | 1.1053 mL | |
| 40 mM | 0.0332 mL | 0.1658 mL | 0.3316 mL | 0.8290 mL | |
| 50 mM | 0.0265 mL | 0.1326 mL | 0.2653 mL | 0.6632 mL | |
| 60 mM | 0.0221 mL | 0.1105 mL | 0.2211 mL | 0.5527 mL | |
| 80 mM | 0.0166 mL | 0.0829 mL | 0.1658 mL | 0.4145 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1326 mL | 0.3316 mL |
Vindesine Related Classifications
HY-16514 Related Classifications
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