2. Stem Cell/Wnt
  3. YAP
  4. YTP-17

YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. YTP-17 shows anti-tumor efficacy.

For research use only. We do not sell to patients.

YTP-17 Chemical Structure

YTP-17 Chemical Structure

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1 mg USD 1580 In-stock
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10 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

YTP-17 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. YTP-17 shows anti-tumor efficacy[1].

IC50 & Target

IC50: 4 nM (YAP-TEAD protein-protein interaction)[1]
In Vitro

YTP-17 shows antiproliferative activity against NCI-H2052 cells with an IC50 of 45 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YTP-17 Related Antibodies
In Vivo

YTP-17 (60 mg/kg; oral gavage; once daily; for 2 weeks) shows anti-tumor efficacy in NCI-H226 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID mice bearing NCI-H226 cells[1]
Dosage: 60 mg/kg, 10 mL/kg
Administration: Oral gavage; once daily; for 2 weeks
Result: A 45% reduction in tumor volume.
Molecular Weight

502.94

Formula

C26H25ClF2N2O4
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC2=C([C@@]([C@@]3=C(C=CC(OCCO)=C3F)C(NC)=O)=C1Cl)C[C@](C4=CC=CC=C4)(CNC)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (198.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9883 mL 9.9415 mL 19.8831 mL
5 mM 0.3977 mL 1.9883 mL 3.9766 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9883 mL 9.9415 mL 19.8831 mL 49.7077 mL
5 mM 0.3977 mL 1.9883 mL 3.9766 mL 9.9415 mL
10 mM 0.1988 mL 0.9942 mL 1.9883 mL 4.9708 mL
15 mM 0.1326 mL 0.6628 mL 1.3255 mL 3.3138 mL
20 mM 0.0994 mL 0.4971 mL 0.9942 mL 2.4854 mL
25 mM 0.0795 mL 0.3977 mL 0.7953 mL 1.9883 mL
30 mM 0.0663 mL 0.3314 mL 0.6628 mL 1.6569 mL
40 mM 0.0497 mL 0.2485 mL 0.4971 mL 1.2427 mL
50 mM 0.0398 mL 0.1988 mL 0.3977 mL 0.9942 mL
60 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8285 mL
80 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.6213 mL
100 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4971 mL
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YTP-17 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YTP-17YTP17YTP 17YAPYes-associated proteinYAP-TEAD protein-protein interactionanti-tumor efficacyInhibitorinhibitorinhibit

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