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Cat. No.: HY-122180

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ZINC08790006

ZINC08790006 is a high-affinity SIRT1 inhibitor, and it can be used in the research of SIRT1-related diseases (such as aging, diabetes and cancer).

For research use only. We do not sell to patients.

CAS No.: 2072170-41-1
Formula: C₁₇H₁₈N₄O₃
Molecular Weight:326.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC08790006 Chemical Structure

CAS No.: 2072170-41-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

ZINC08790006 is a high-affinity SIRT1 inhibitor, and it can be used in the research of SIRT1-related diseases (such as aging, diabetes and cancer)^[1]^[2].

IC₅₀ & Target^[1]

SIRT1

All Sirtuin Isoforms :

In Vitro

ZINC08790006 exhibits high affinity for the catalytic domain of SIRT1 (PDB ID: 4I5I), with an estimated binding energy of −7.3 kcal/mol, which is consistent with the structural characteristics of potent SIRT1 inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2072170-41-1
Molecular Weight 326.35
Formula C₁₇H₁₈N₄O₃
SMILES

O=C1N(C)C(C(C2N(C)CCC3=C2NC4=C3C=CC=C4)=C(O)N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products. Scientific reports. 2016 Jan 25;6:19312. [Content Brief]

[2]. Alrouji M, et al. Targeting Sirtuin 1 for therapeutic potential: Drug repurposing approach integrating docking and molecular dynamics simulations. PloS one. 2023;18(12):e0293185.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ZINC08790006

All Sirtuin Isoforms