ZK164015
Based on 1 Customer Validation
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 177583-70-9
- Formula: C30H43NO4S
- Molecular Weight:513.73
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cancer cell lines | IC50 |
0.02 μM
Compound: ZK-164015
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Inhibition of 10e-9 M E2 stimulated transcriptional activation in ER+MCF-7/2a breast cancer cells
Inhibition of 10e-9 M E2 stimulated transcriptional activation in ER+MCF-7/2a breast cancer cells
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[PMID: 15324884] |
| Cancer cell lines | IC50 |
0.05 μM
Compound: ZK-164015
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Inhibition of 10e-9 M E2 stimulated MCF-7 breast cancer cell proliferation
Inhibition of 10e-9 M E2 stimulated MCF-7 breast cancer cell proliferation
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[PMID: 15324884] |
| Cancer cell lines | IC50 |
1.4 nM
Compound: ZK-164015
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Inhibition of ER-MDA-MB 231 breast cancer cell proliferation over 200 hr
Inhibition of ER-MDA-MB 231 breast cancer cell proliferation over 200 hr
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[PMID: 15324884] |
Chemical Information
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CAS No. 177583-70-9
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Appearance Solid
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Molecular Weight 513.73
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Formula C30H43NO4S
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Color Off-white to light yellow
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SMILES
OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (194.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9465 mL | 9.7327 mL | 19.4655 mL | 48.6637 mL |
| 5 mM | 0.3893 mL | 1.9465 mL | 3.8931 mL | 9.7327 mL | |
| 10 mM | 0.1947 mL | 0.9733 mL | 1.9465 mL | 4.8664 mL | |
| 15 mM | 0.1298 mL | 0.6488 mL | 1.2977 mL | 3.2442 mL | |
| 20 mM | 0.0973 mL | 0.4866 mL | 0.9733 mL | 2.4332 mL | |
| 25 mM | 0.0779 mL | 0.3893 mL | 0.7786 mL | 1.9465 mL | |
| 30 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 40 mM | 0.0487 mL | 0.2433 mL | 0.4866 mL | 1.2166 mL | |
| 50 mM | 0.0389 mL | 0.1947 mL | 0.3893 mL | 0.9733 mL | |
| 60 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8111 mL | |
| 80 mM | 0.0243 mL | 0.1217 mL | 0.2433 mL | 0.6083 mL | |
| 100 mM | 0.0195 mL | 0.0973 mL | 0.1947 mL | 0.4866 mL |
ZK164015 Related Classifications
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