2. PROTAC
  3. PROTACs
  4. ZXH-4-130

ZXH-4-130 is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC).

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ZXH-4-130

ZXH-4-130 Estructura química

No. CAS : 2711006-66-3

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 2 publication(s) in Google Scholar

Other Forms of ZXH-4-130:

ZXH-4-130 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Descripciòn

ZXH-4-130 is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC)[1].

IC50 & Target[1]

VHL

 

In Vitro

ZXH-4-130 (100 nM; 2 h pre-treatments; followed by 96-hour treatment with 1 μM of Pomalidomide) prevents Pomalidomide (1 μM) cytotoxicity to a significant extent, ZXH-4-130 has statistically significant amounts of prevention[1].
MM1.S cells are pre-treated for 2 h with 50 nM of ZXH-4-130, before exposing them to CC-885, a compound that induces G1 to S phase transition protein 1 (GSPT1) degradation via CRBN E3 ligase recruitment. Pretreatment with 50 nM of ZXH-4-130 rescues GSPT1 degradation[1].
ZXH-4-130 (100 nM 2 h pre-treatment; followed by 6 h treatment with THAL-SNS-032) induces nearly complete CRBN degradation, but THAL-SNS-032's activity against CDK9 is only partially prevented[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZXH-4-130 Related Antibodies

Cell Viability Assay[1]

Cell Line: MM1.S cells
Concentration: 100 nM
Incubation Time: 2 h pre-treatments; followed by 96-hour treatment with 1 μM of Pomalidomide
Result: Prevented Pomalidomide cytotoxicity to a significant extent, ZXH-4-130 has statistically significant amounts of prevention.

Western Blot Analysis[1]

Cell Line: MM1.S cells
Concentration: 50 nM
Incubation Time: 2 h pretreatment with ZXH-4-130, followed by 4 h treatment with CC-885
Result: Rescued GSPT1 degradation.
Peso molecular

871.05

Fòrmula

C46H58N6O9S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 25 mg/mL (28.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1480 mL 5.7402 mL 11.4804 mL
5 mM 0.2296 mL 1.1480 mL 2.2961 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1480 mL 5.7402 mL 11.4804 mL 28.7010 mL
5 mM 0.2296 mL 1.1480 mL 2.2961 mL 5.7402 mL
10 mM 0.1148 mL 0.5740 mL 1.1480 mL 2.8701 mL
15 mM 0.0765 mL 0.3827 mL 0.7654 mL 1.9134 mL
20 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4350 mL
25 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1480 mL
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ZXH-4-130 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZXH-4-1302711006-66-3PROTACsInhibitorinhibitorinhibit

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Nombre del producto:
ZXH-4-130
Cat. No.:
HY-132857
Cantidad:
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