1. Apoptosis
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Apoptosis
    Reactive Oxygen Species
    COX
  3. β-Elemonic acid

β-Elemonic acid 

Cat. No.: HY-N2454
Handling Instructions

β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.

For research use only. We do not sell to patients.

β-Elemonic acid Chemical Structure

β-Elemonic acid Chemical Structure

CAS No. : 28282-25-9

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Description

β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].

IC50 & Target

COX-2

 

In Vitro

β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner[1].
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 µM[1].
β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase[1].
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells[1].

Molecular Weight

454.68

Formula

C₃₀H₄₆O₃

CAS No.

28282-25-9

SMILES

C[[email protected]@]12C3=C(CC[[email protected]]1([[email protected]@]([[email protected]@H](C(O)=O)CC/C=C(C)/C)([H])CC2)C)[[email protected]@]4([[email protected]@](C(C)(C(CC4)=O)C)([H])CC3)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

β-Elemonic acidApoptosisReactive Oxygen SpeciesCOXCyclooxygenaseTriterpeneBoswelliapapyriferaAnticanceranti-inflammatoryhumanA549lungcancerInhibitorinhibitorinhibit

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β-Elemonic acid
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HY-N2454
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