1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. PPAR
    Endogenous Metabolite
  3. 15-Deoxy-Δ-12,14-prostaglandin J2

15-Deoxy-Δ-12,14-prostaglandin J2 (Synonyms: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2)

Cat. No.: HY-108568
Handling Instructions

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.

For research use only. We do not sell to patients.

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

CAS No. : 87893-55-8

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Description

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

IC50 & Target[1]

PPARγ

2 μM (EC50)

PPARδ

 

Human Endogenous Metabolite

 

In Vitro

15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].

Molecular Weight

316.43

Formula

C₂₀H₂₈O₃

CAS No.

87893-55-8

SMILES

CCCCC/C=C/C=C1[[email protected]](C=CC\1=O)C/C=C\CCCC(O)=O

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

15-Deoxy-Δ-12,14-prostaglandin J215d-PGJ215-Deoxy-Δ12,14-PGJ2PPAREndogenous MetabolitePeroxisome proliferator-activated receptorsEnonePPARγPPARδcyclopentenoneprostaglandincovalentCys249Inhibitorinhibitorinhibit

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15-Deoxy-Δ-12,14-prostaglandin J2
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HY-108568
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