(1R)-AZD-1480
Based on 1 Customer Validation
(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor.
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- Reinheit: 97.62%
- CAS. Nr.: 935666-99-2
- Formel: C14H14ClFN8
- Molecular Weight:348.77
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
11 μM
Compound: 21
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Growth inhibition of mouse BA/F3 cells expressing Tel-JAK2 kinase after 48 hrs by MTS assay
Growth inhibition of mouse BA/F3 cells expressing Tel-JAK2 kinase after 48 hrs by MTS assay
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[PMID: 21138246] |
Chemical Information
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CAS. Nr. 935666-99-2
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Appearance Solid
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Molecular Weight 348.77
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Formel C14H14ClFN8
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Color White to off-white
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SMILES
ClC1=C(N=C(N=C1)N[C@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (286.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8672 mL | 14.3361 mL | 28.6722 mL | 71.6805 mL |
| 5 mM | 0.5734 mL | 2.8672 mL | 5.7344 mL | 14.3361 mL | |
| 10 mM | 0.2867 mL | 1.4336 mL | 2.8672 mL | 7.1680 mL | |
| 15 mM | 0.1911 mL | 0.9557 mL | 1.9115 mL | 4.7787 mL | |
| 20 mM | 0.1434 mL | 0.7168 mL | 1.4336 mL | 3.5840 mL | |
| 25 mM | 0.1147 mL | 0.5734 mL | 1.1469 mL | 2.8672 mL | |
| 30 mM | 0.0956 mL | 0.4779 mL | 0.9557 mL | 2.3893 mL | |
| 40 mM | 0.0717 mL | 0.3584 mL | 0.7168 mL | 1.7920 mL | |
| 50 mM | 0.0573 mL | 0.2867 mL | 0.5734 mL | 1.4336 mL | |
| 60 mM | 0.0478 mL | 0.2389 mL | 0.4779 mL | 1.1947 mL | |
| 80 mM | 0.0358 mL | 0.1792 mL | 0.3584 mL | 0.8960 mL | |
| 100 mM | 0.0287 mL | 0.1434 mL | 0.2867 mL | 0.7168 mL |
(1R)-AZD-1480 Related Classifications
HY-10193A Related Classifications
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