2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Apoptosis
  3. Herbicide DNA/RNA Synthesis Apoptosis
  4. 2,4-D ammonium

2,4-D ammonium  (Synonyms: 2,4-Dichlorophenoxyacetic acid ammonium)

Cat. No.: HY-W547534
Handling Instructions Technical Support

2,4-D (2, 4-dichlorophenoxyacetic acid) ammonium is a selective herbicide that can be used for the control of broad-leaved weeds. 2,4-D ammonium can induce apoptosis. 2,4-D ammonium inhibits DNA and protein synthesis, thereby preventing normal plant growth and development.

For research use only. We do not sell to patients.

2,4-D ammonium

2,4-D ammonium Chemical Structure

CAS No. : 2307-55-3

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2,4-D ammonium Related Antibodies

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Description

2,4-D (2, 4-dichlorophenoxyacetic acid) ammonium is a selective herbicide that can be used for the control of broad-leaved weeds. 2,4-D ammonium can induce apoptosis. 2,4-D ammonium inhibits DNA and protein synthesis, thereby preventing normal plant growth and development[1][2][3].

In Vitro

2, 4-D (25-200 μM, 72 h) ammonium inhibits the cell viability of A549 and WI38 with IC50 values of 126 µM and 115 µM, respectively. Induces apoptosis by influencing the cell cycle[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,4-D ammonium Related Antibodies

Cell Viability Assay[2]

Cell Line: A549, W138
Concentration: 25, 50, 75, 100, 150, 200 μM
Incubation Time: 72 h
Result: Inhibited cell viability in a dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: A549
Concentration: 50, 100, 150 μM
Incubation Time: 72 h
Result: The G0/G1 population decreased to about 57%, 43% and 31%, respectively.

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: A549, W138
Concentration: 100, 150 μM
Incubation Time: 72 h
Result: The early apoptotic population increased to 44% in A549 cells and 57% in WI38 cells, and the late apoptotic population increased to 18% in A549 cells and 10% in WI38 cells.

Western Blot Analysis[2]

Cell Line: A549, W138
Concentration: 100, 150 μM
Incubation Time: 72 h
Result: Up-regulated p53 and Bax proteins, down-regulated Bcl-2 and procaspase 3.
In Vivo

2,4-D (100 or 200 mg/kg, gavage for 30 days) ammonium has toxic effects on the reproductive system of male rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Wistar male rats[3]
Dosage: 100 or 200 mg/kg
Administration: i.g.
Result: Decreased the testis, seminal vesicles and prostate relative weight.
Decreased the number of spermatozoa and sperm motility.
Increased the level of FSH and LH.
Molecular Weight

238.07

Formula

C8H9Cl2NO3
CAS No.
SMILES

O=C(COC1=CC=C(C=C1Cl)Cl)O.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2,4-D ammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,4-D2307-55-32,4-Dichlorophenoxyacetic acidHerbicideDNA/RNA SynthesisApoptosisabscisic acidcaspase-3apoptosistobacco BY-2 suspension cellp53DNA ligase 4ethylene metabolic pathwaysnon-homologous end joiningzebrafish larvaeDNA repairInhibitorinhibitorinhibit

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