2,4-D ammonium
Based on 1 publication(s) in Google Scholar
2,4-D (2, 4-dichlorophenoxyacetic acid) ammonium is a selective herbicide that can be used for the control of broad-leaved weeds. 2,4-D ammonium can induce apoptosis. 2,4-D ammonium inhibits DNA and protein synthesis, thereby preventing normal plant growth and development.
For research use only. We do not sell to patients.
- CAS No.: 2307-55-3
- Formula: C8H9Cl2NO3
- Molecular Weight:238.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2,4-D ammonium
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Biological Activity
2, 4-D (25-200 μM, 72 h) ammonium inhibits the cell viability of A549 and WI38 with IC50 values of 126 µM and 115 µM, respectively. Induces apoptosis by influencing the cell cycle[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, W138
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Concentration:25, 50, 75, 100, 150, 200 μM
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Incubation Time:72 h
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Result:Inhibited cell viability in a dose-dependent manner.
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Cell Line:A549
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Concentration:50, 100, 150 μM
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Incubation Time:72 h
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Result:The G0/G1 population decreased to about 57%, 43% and 31%, respectively.
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Cell Line:A549, W138
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Concentration:100, 150 μM
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Incubation Time:72 h
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Result:The early apoptotic population increased to 44% in A549 cells and 57% in WI38 cells, and the late apoptotic population increased to 18% in A549 cells and 10% in WI38 cells.
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Cell Line:A549, W138
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Concentration:100, 150 μM
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Incubation Time:72 h
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Result:Up-regulated p53 and Bax proteins, down-regulated Bcl-2 and procaspase 3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult Wistar male rats[3]
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Dosage:100 or 200 mg/kg
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Administration:i.g.
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Result:Decreased the testis, seminal vesicles and prostate relative weight.
Decreased the number of spermatozoa and sperm motility.
Increased the level of FSH and LH.
Chemical Information
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CAS No. 2307-55-3
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Molecular Weight 238.07
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Formula C8H9Cl2NO3
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SMILES
O=C(COC1=CC=C(C=C1Cl)Cl)O.N
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Synonyms
2,4-Dichlorophenoxyacetic acid ammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Purity & Documentation
References
[1]. Germaine KJ, et al. Bacterial endophyte-enhanced phytoremediation of the organochlorine herbicide 2,4-dichlorophenoxyacetic acid. FEMS Microbiol Ecol. 2006 Aug;57(2):302-10. [Content Brief]
[3]. Marouani N, et al. Effects of oral administration of 2,4-dichlorophenoxyacetic acid (2,4-D) on reproductive parameters in male Wistar rats. Environ Sci Pollut Res Int. 2017 Jan;24(1):519-526. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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