22(R)-Hydroxycholesterol-d7
22(R)-Hydroxycholesterol-d7 (Narthesterol-d7) is the deuterated-labeled 22(R)-Hydroxycholesterol (HY-116969). 22 (R)-Hydroxycholesterol (Narthesterol) is a natural oxysterol, acting as a LXRα agonist that inhibits cancer cell proliferation. 22 (R)-Hydroxycholesterol activates LXRα-mediated upregulation of downstream ABCA1 expression, enhances apolipoprotein-dependent cholesterol efflux, reduces intracellular cholesterol content, and decreases the production of β-amyloid peptide. 22 (R)-Hydroxycholesterol induces the differentiation of human mesenchymal stem cells into functional dopaminergic neurons. 22 (R)-Hydroxycholesterol is applicable to research related to cancer, Alzheimer's disease, and Parkinson's disease.
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- No. CAS: 1246302-93-1
- Fòrmula: C27H39D7O2
- Peso molecular:409.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1246302-93-1
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Unlabeled CAS 17954-98-2
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Peso molecular 409.70
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Fòrmula C27H39D7O2
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)[C@H](O)CCC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
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Synonyms
Narthesterol-d7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
22(R)-Hydroxycholesterol-d7 Related Classifications
HY-116969S Related Classifications
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Keywords
- 22(R)-Hydroxycholesterol-d7
- 1246302-93-1
- Narthesterol-d7
- Isotope-Labeled Compounds
- Endogenous Metabolite
- LXR
- Amyloid-β
- ATP-binding cassette (ABC) transporters
- Liver X receptor
- CHOAPPsw cells
- LXRα
- retinoic X receptor
- LNCaP human prostate cancer cell sublines
- H4APPsw cells
- ATP-binding cassette transporter A1
- human mesenchymal stem cells
- amyloid precursor protein
- HEK293 cells
- Inhibitor
- inhibitor
- inhibit