3-Hydroxypyridine
Based on 1 Customer Validation
3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 109-00-2
- Formula: C5H5NO
- Molecular Weight:95.10
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Natural Product Library
HY-L021
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Anti-Aging Compound Library
HY-L034
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Oxygen Sensing Compound Library
HY-L045
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Medicine Food Homology Compound Library
HY-L055
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Alkaloids Library
HY-L071
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Gut Microbial Metabolite Library
HY-L078
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Microbial Metabolite Library
HY-L084
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Anti-inflammatory Traditional Chinese Medicine Active Compound Library
HY-L114
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Heterocyclic Compound Library
HY-L138
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Natural Product Library Plus
HY-L021P
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Natural Product and Natural Product-Like Compound Library
HY-L021M
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Bioactive Compound Library
HY-L001
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Tibetan Medicine Compound Library
HY-L191
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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RO5 Drug-like Natural Product Library
HY-L200
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High-Throughput Bioactive Compound Library
HY-L205
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High-Throughput Natural Product Library
HY-L206
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Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
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Mongolian Medicine Compound Library
HY-L238
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Chinese Baijiu Compound Library
HY-L241
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Drug Fragment Library
HY-L904
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| MIA PaCa-2 | IC50 |
56480 nM
Compound: S34, r1c8
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Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay
Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay
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[PMID: 17944451] |
| MIA PaCa-2 | IC50 |
73100 nM
Compound: S34, r1c8
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Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
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[PMID: 17944451] |
| MRC5 | IC50 |
>500 μM
Compound: 2c
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Cytostatic activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytostatic activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29289891] |
| T98G | IC50 |
>500 μM
Compound: 2c
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Cytostatic activity against human T98G cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytostatic activity against human T98G cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29289891] |
| U-118-MG | IC50 |
>500 μM
Compound: 2c
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Cytostatic activity against human U118MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytostatic activity against human U118MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29289891] |
| U-87MG ATCC | IC50 |
>500 μM
Compound: 2c
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Cytostatic activity against human U87MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytostatic activity against human U87MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29289891] |
Chemical Information
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CAS No. 109-00-2
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Appearance Solid
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Molecular Weight 95.10
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Formula C5H5NO
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Color White to off-white
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SMILES
OC1=CC=CN=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 110 mg/mL (1156.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4.23 mg/mL (44.48 mM); Clear solution
This protocol yields a clear solution of ≥ 4.23 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (42.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.75 mg/mL (28.92 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.75 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 10.5152 mL | 52.5762 mL | 105.1525 mL | 262.8812 mL |
| 5 mM | 2.1030 mL | 10.5152 mL | 21.0305 mL | 52.5762 mL | |
| 10 mM | 1.0515 mL | 5.2576 mL | 10.5152 mL | 26.2881 mL | |
| 15 mM | 0.7010 mL | 3.5051 mL | 7.0102 mL | 17.5254 mL | |
| 20 mM | 0.5258 mL | 2.6288 mL | 5.2576 mL | 13.1441 mL | |
| 25 mM | 0.4206 mL | 2.1030 mL | 4.2061 mL | 10.5152 mL | |
| 30 mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 8.7627 mL | |
| 40 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 6.5720 mL | |
| 50 mM | 0.2103 mL | 1.0515 mL | 2.1030 mL | 5.2576 mL | |
| 60 mM | 0.1753 mL | 0.8763 mL | 1.7525 mL | 4.3814 mL | |
| 80 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 3.2860 mL | |
| 100 mM | 0.1052 mL | 0.5258 mL | 1.0515 mL | 2.6288 mL |
3-Hydroxypyridine Related Classifications
HY-Y1129 Related Classifications
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