4-Oxoetodolac
4-Oxoetodolac, Etodolac (HY-76251) metabolite, is an orally active antiinflammatory agent. 4-Oxoetodolac blocks prostaglandin production in cultured chondrocyte cells. 4-Oxoetodolac exhibits slight antiinflammatory activity in a rat adjuvant edema model. 4-Oxoetodolac can be used for the research of inflammation.
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- CAS No.: 111478-86-5
- Formule: C17H19NO4
- Masse moléculaire:301.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
4-Oxoetodolac (Comppound 6) inhibits prostaglandin E2 production in cultured chondrocyte cells with an IC50 of 18.5 × 10-8 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 180-200 g, CFA (HY-153808)-induced edema model)[1]
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Dosage:25 mg/kg
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Administration:p.o.; 3 doses (day 0, day 1, day 2)
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Result:Produced 21% inhibition of adjuvant-induced hindpaw edema with statistical significance relative to vehicle control.
Chemical Information
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CAS No. 111478-86-5
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Masse moléculaire 301.34
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Formule C17H19NO4
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SMILES
O=C(O)CC1(OCC(=O)C=2C=3C=CC=C(C3NC21)CC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Oxoetodolac Related Classifications
HY-W740009 Related Classifications
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