2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Drug Metabolite Prostaglandin Receptor
  4. 4-Oxoetodolac

4-Oxoetodolac, Etodolac (HY-76251) metabolite, is an orally active antiinflammatory agent. 4-Oxoetodolac blocks prostaglandin production in cultured chondrocyte cells. 4-Oxoetodolac exhibits slight antiinflammatory activity in a rat adjuvant edema model. 4-Oxoetodolac can be used for the research of inflammation.

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4-Oxoetodolac

4-Oxoetodolac Chemical Structure

CAS No. : 111478-86-5

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4-Oxoetodolac Related Antibodies

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Description

4-Oxoetodolac, Etodolac (HY-76251) metabolite, is an orally active antiinflammatory agent. 4-Oxoetodolac blocks prostaglandin production in cultured chondrocyte cells. 4-Oxoetodolac exhibits slight antiinflammatory activity in a rat adjuvant edema model. 4-Oxoetodolac can be used for the research of inflammation[1].

In Vitro

4-Oxoetodolac (Comppound 6) inhibits prostaglandin E2 production in cultured chondrocyte cells with an IC50 of 18.5 × 10-8 M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Oxoetodolac Related Antibodies
In Vivo

4-Oxoetodolac (Compound 6) (25 mg/kg; i.g.; 3 doses (day 0, day 1, day 2) produces a statistically significant 21% inhibition of CFA (HY-153808)-induced hindpaw edema in male Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 180-200 g, CFA (HY-153808)-induced edema model)[1]
Dosage: 25 mg/kg
Administration: p.o.; 3 doses (day 0, day 1, day 2)
Result: Produced 21% inhibition of adjuvant-induced hindpaw edema with statistical significance relative to vehicle control.
Molecular Weight

301.34

Formula

C17H19NO4
CAS No.
SMILES

O=C(O)CC1(OCC(=O)C=2C=3C=CC=C(C3NC21)CC)CC
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References
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4-Oxoetodolac Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Oxoetodolac111478-86-5Drug MetaboliteProstaglandin ReceptorSprague-Dawley ratschondrocyte cellsprostaglandin E2adjuvantCFAhindpaw edemaInhibitorinhibitorinhibit

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