4-Oxoetodolac
4-Oxoetodolac, Etodolac (HY-76251) metabolite, is an orally active antiinflammatory agent. 4-Oxoetodolac blocks prostaglandin production in cultured chondrocyte cells. 4-Oxoetodolac exhibits slight antiinflammatory activity in a rat adjuvant edema model. 4-Oxoetodolac can be used for the research of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 111478-86-5
- Formula: C17H19NO4
- Molecular Weight:301.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
4-Oxoetodolac (Comppound 6) inhibits prostaglandin E2 production in cultured chondrocyte cells with an IC50 of 18.5 × 10-8 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague-Dawley (male, 180-200 g, CFA (HY-153808)-induced edema model)[1]
-
Dosage:25 mg/kg
-
Administration:p.o.; 3 doses (day 0, day 1, day 2)
-
Result:Produced 21% inhibition of adjuvant-induced hindpaw edema with statistical significance relative to vehicle control.
Chemical Information
-
CAS No. 111478-86-5
-
Molecular Weight 301.34
-
Formula C17H19NO4
-
SMILES
O=C(O)CC1(OCC(=O)C=2C=3C=CC=C(C3NC21)CC)CC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Oxoetodolac Related Classifications
HY-W740009 Related Classifications
Powered by Bioz