7β-Hydroxy-epi-androsterone
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone.
For research use only. We do not sell to patients.
- CAS No.: 25848-69-5
- Formula: C19H30O3
- Molecular Weight:306.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERβ |
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 72 h) inhibits MCF-7 and MDA-MB-231 cell proliferation in the presence of E2 (10 nM)[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) leads to a G0/G1 cell cycle arrest in MCF-7 and MDA-MB-231 cells[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) increases cell apoptosis in the presence of E2 (10 nM) in MCF-7 cells[2].
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 24 h) binds to ERβ and decreases in transactivation in MDA-MB-231 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1, 10 and 100 nM (in presence of 10 nM E2)
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Incubation Time:48 h
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Result:Increased cell apoptosis in presence of E2.
7β-Hydroxy-epi-androsterone (0.1 mg/kg s.c., b.i.d. for 10 days) shows protective effect against inflammatory neurodegeneration and glial cell death in Alzheimer's disease rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat with DSS-induced colitis[3]
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Dosage:0.01, 0.1 and 1 mg/kg
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Administration:Intraperitoneal injection (i.p.), once a day for 7 days.
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Result:Increased in COX-2 and PGE synthase expression.
Increased colonic tissue levels of 15d-PGJ2 levels.
Chemical Information
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CAS No. 25848-69-5
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Molecular Weight 306.44
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Formula C19H30O3
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SMILES
C[C@@]12[C@]3([H])[C@]([C@@H](O)C[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3
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Synonyms
7β-Hydroxy-EpiA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77(5):542-51. [Content Brief]
[3]. Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):255-62. [Content Brief]
[4]. Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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