1. Immunology/Inflammation
  2. COX
  3. Amfenac Sodium Hydrate

Amfenac Sodium Hydrate 

Cat. No.: HY-17479A Purity: 98.65%
Handling Instructions

Amfenac Sodium Hydrate is a COX-2 inhibitor.

For research use only. We do not sell to patients.

Amfenac Sodium Hydrate Chemical Structure

Amfenac Sodium Hydrate Chemical Structure

CAS No. : 61618-27-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Amfenac Sodium Hydrate is a COX-2 inhibitor.

IC50 & Target[1]

COX-2

 

In Vitro

Cells transfected to express COX-2 have a higher proliferation rate than those do not. The addition of Amfenac Sodium Hydrate significantly decreases the proliferation rate of all cell lines. Nitric oxide production by macrophages is inhibited by the addition of melanoma conditioned medium, the addition of Amfenac Sodium Hydrate partially overcomes this inhibition[1]. Results show that Amfenac Sodium Hydrate inhibits the release of B-glucuronidase: 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[2].

Molecular Weight

295.27

Formula

C₁₅H₁₄NNaO₄

CAS No.

61618-27-7

SMILES

O=C([O-])CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N.[H]O[H].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (508.01 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3867 mL 16.9337 mL 33.8673 mL
5 mM 0.6773 mL 3.3867 mL 6.7735 mL
10 mM 0.3387 mL 1.6934 mL 3.3867 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Amfenac Sodium Hydrate
Cat. No.:
HY-17479A
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