1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mAChR
    Drug Metabolite
  3. Clozapine (N-oxide)

Clozapine (N-oxide) 

製品番号: HY-17366 純度: 99.98%
取扱説明書

Clozapine (N-oxide), a metabolite of Clozapine, is an agonist for the human muscarinic designer receptors (DREADDs). Clozapine is a potent antagonist of dopamine. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

Clozapine (N-oxide) 構造式

Clozapine (N-oxide) 構造式

CAS 番号 : 34233-69-7

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 79 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 108 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 420 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 672 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of Clozapine (N-oxide):

Top Publications Citing Use of Products

    Clozapine (N-oxide) purchased from MCE. Usage Cited in: Biol Psychiatry. 2017 May 1;81(9):737-747.

    c-fos immunoreactivity in the VTA 90 minutes after injections of 1 mg/kg Clozapine N-oxide (CNO).
    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Clozapine (N-oxide), a metabolite of Clozapine, is an agonist for the human muscarinic designer receptors (DREADDs)[1][2]. Clozapine is a potent antagonist of dopamine. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[3][4].

    体内実験

    After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig. The metabolites that may form after chronic administration of CNO to DREADD-expressing mice (or other species) have not been studied systematically. However, even if back-transformation to Clozapine occurs after chronic CNO administration, it should be noted that Clozapine is a more potent (by ~10-fold) DREADD agonist than CNO itself. Moreover, confounding biological effects of potential CNO metabolites can be easily identified by including both saline- and CNO-treated WT animals in a particular DREADD study. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h). One possibility is that CNO tends to accumulate in tissues, although other scenarios are also feasible[1].
    Using a general pharmacokinetic model for the interconversion process, the mean total clearances of Clozapine and Clozapine N-oxide (CNO) are 28.45 L/hr and 45.30 L/hr, respectively[2].

    分子量

    342.82

    分子式

    C₁₈H₁₉ClN₄O

    CAS 番号

    34233-69-7

    SMILES

    [O-][N+]1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 100 mg/mL (291.70 mM)

    Methanol : ≥ 28.6 mg/mL (83.43 mM)

    H2O : 1 mg/mL (2.92 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9170 mL 14.5849 mL 29.1698 mL
    5 mM 0.5834 mL 2.9170 mL 5.8340 mL
    10 mM 0.2917 mL 1.4585 mL 2.9170 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.29 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献

    純度: 99.98%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • モル濃度カルキュレーター

    • 希釈カルキュレーター

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Clozapine (N-oxide)mAChRDrug MetaboliteMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

     

    タイトル

    お名前 *

     

    PC 用メールアドレス *

    電話番号 *

     

    勤務先/学校名 *

    国会或いは地域 *

     

    カスタマ需要量 *

    メッセージ

    バルクお問い合わせ

    Inquiry Information

    製品名:
    Clozapine (N-oxide)
    製品番号:
    HY-17366
    数量:
    MCE 日本正規代理店: