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Cat. No.: HY-111368

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EBI-1051

EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC₅₀ of 3.9 nM.

For research use only. We do not sell to patients.

CAS No.: 1801896-05-8
Formula: C₁₈H₁₅F₂IN₂O₅
Molecular Weight:504.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

EBI-1051 Chemical Structure

CAS No.: 1801896-05-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC₅₀ of 3.9 nM.

IC₅₀ & Target

IC50: 3.9 nM (MEK)^[1]

All MEK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	4.7 nM Compound: 28d	Antiproliferative activity against human COLO205 cells harboring BRAF mutant/wild type KRAS/wild type PIK3CA after 72 hrs by CCK8 assay Antiproliferative activity against human COLO205 cells harboring BRAF mutant/wild type KRAS/wild type PIK3CA after 72 hrs by CCK8 assay	[PMID: 29317148]

Chemical Information

CAS No. 1801896-05-8
Molecular Weight 504.22
Formula C₁₈H₁₅F₂IN₂O₅
SMILES

O=C(NOC(CO)CO)C1=C(NC2=CC=C(I)C=C2F)C(F)=C3C(C=CO3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu B, et al. Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold. Bioorg Med Chem. 2018 Feb 1;26(3):581-589. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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EBI-1051

All MEK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EBI-1051 Related Classifications

HY-111368 Related Classifications