1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

D-(+)-Glucono-1,5-lactone (Synonyms: Gluconic acid lactone)

Cat. No.: HY-I0301 Purity: >98.0%
Handling Instructions

D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

For research use only. We do not sell to patients.

D-(+)-Glucono-1,5-lactone Chemical Structure

D-(+)-Glucono-1,5-lactone Chemical Structure

CAS No. : 90-80-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
5 g USD 50 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

IC50 & Target

Human Endogenous Metabolite


In Vitro

D-(+)-Glucono-1,5-lactone is a lactone (cyclic ester) of D-gluconic acid. D-(+)-Glucono-1,5-lactone is commonly found in honey, fruit juices, personal lubricants, and wine. D-(+)-Glucono-1,5-lactone is neutral, but hydrolyses in water to gluconic acid which is acidic, adding a tangy taste to foods, though it has roughly a third of the sourness of citric acid. It is metabolized to glucose; one gram of D-(+)-Glucono-1,5-lactone yields roughly the same amount of metabolicenergy as one gram of sugar. Upon addition to water, GDL is partially hydrolysed to gluconic acid, with the balance between the lactone form and the acid form established as a chemical equilibrium. The rate of hydrolysis of D-(+)-Glucono-1,5-lactone is increased by heat and high pH[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6136 mL 28.0678 mL 56.1356 mL
5 mM 1.1227 mL 5.6136 mL 11.2271 mL
10 mM 0.5614 mL 2.8068 mL 5.6136 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C1[[email protected]](O)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](CO)O1

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name



Applicant name *


Email address *

Phone number *


Organization name *

Country or Region *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product Name:
Cat. No.:


Cat. No.: HY-I0301