1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Reactive Oxygen Species
  3. D-(+)-Glucono-1,5-lactone

D-(+)-Glucono-1,5-lactone (Synonyms: Gluconic acid lactone)

Cat. No.: HY-I0301 Purity: >98.0%
Handling Instructions

D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

For research use only. We do not sell to patients.

D-(+)-Glucono-1,5-lactone Chemical Structure

D-(+)-Glucono-1,5-lactone Chemical Structure

CAS No. : 90-80-2

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Based on 1 publication(s) in Google Scholar

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D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

IC50 & Target

Human Endogenous Metabolite


In Vitro

D-(+)-Glucono-1,5-lactone is a lactone (cyclic ester) of D-gluconic acid. D-(+)-Glucono-1,5-lactone is commonly found in honey, fruit juices, personal lubricants, and wine. D-(+)-Glucono-1,5-lactone is neutral, but hydrolyses in water to gluconic acid which is acidic, adding a tangy taste to foods, though it has roughly a third of the sourness of citric acid. It is metabolized to glucose; one gram of D-(+)-Glucono-1,5-lactone yields roughly the same amount of metabolicenergy as one gram of sugar. Upon addition to water, GDL is partially hydrolysed to gluconic acid, with the balance between the lactone form and the acid form established as a chemical equilibrium. The rate of hydrolysis of D-(+)-Glucono-1,5-lactone is increased by heat and high pH[1].

Molecular Weight







Room temperature in continental US; may vary elsewhere

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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