1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. JNJ-61432059

JNJ-61432059 

Cat. No.: HY-111751
Handling Instructions

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

For research use only. We do not sell to patients.

JNJ-61432059 Chemical Structure

JNJ-61432059 Chemical Structure

CAS No. : 2035814-50-5

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Description

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

IC50 & Target

pIC50: 9.7 (AMPAR)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

443.47

Formula

C₂₅H₂₂FN₅O₂

CAS No.

2035814-50-5

SMILES

OC1CCN(C2=NC=CC3=C(C4=CC=C(NC(C5)=O)C5=C4)C(C6=CC=C(F)C=C6)=NN32)CC1

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Room temperature in continental US; may vary elsewhere

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JNJ-61432059
Cat. No.:
HY-111751
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Cat. No.: HY-111751