1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. LAS-31180

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

For research use only. We do not sell to patients.

LAS-31180 Chemical Structure

LAS-31180 Chemical Structure

CAS No. : 137338-43-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

In Vitro

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

252.29

Formula

C11H12N2O3S

CAS No.
SMILES

CS(=O)(NC1=CN(C)C2=C(C=CC=C2)C1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LAS-31180 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LAS-31180
Cat. No.:
HY-101811
Quantity:
MCE Japan Authorized Agent: