2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Loviride

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells.

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Loviride Chemical Structure

Loviride Chemical Structure

CAS No. : 147362-57-0

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Loviride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].

IC50 & Target

IC50: 0.3 µM (Reverse transcriptase)[1]
In Vitro

Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Loviride Related Antibodies
Molecular Weight

351.23

Formula

C17H16Cl2N2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N)C(NC1=C(C(C)=O)C=CC(C)=C1)C2=C(Cl)C=CC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (177.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8471 mL 14.2357 mL 28.4714 mL
5 mM 0.5694 mL 2.8471 mL 5.6943 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 6.25 mg/mL (17.79 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8471 mL 14.2357 mL 28.4714 mL 71.1784 mL
5 mM 0.5694 mL 2.8471 mL 5.6943 mL 14.2357 mL
10 mM 0.2847 mL 1.4236 mL 2.8471 mL 7.1178 mL
15 mM 0.1898 mL 0.9490 mL 1.8981 mL 4.7452 mL
20 mM 0.1424 mL 0.7118 mL 1.4236 mL 3.5589 mL
25 mM 0.1139 mL 0.5694 mL 1.1389 mL 2.8471 mL
30 mM 0.0949 mL 0.4745 mL 0.9490 mL 2.3726 mL
40 mM 0.0712 mL 0.3559 mL 0.7118 mL 1.7795 mL
50 mM 0.0569 mL 0.2847 mL 0.5694 mL 1.4236 mL
60 mM 0.0475 mL 0.2373 mL 0.4745 mL 1.1863 mL
80 mM 0.0356 mL 0.1779 mL 0.3559 mL 0.8897 mL
100 mM 0.0285 mL 0.1424 mL 0.2847 mL 0.7118 mL
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Loviride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Loviride147362-57-0R 89439R89439R-89439Reverse TranscriptaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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