1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. Mirk-IN-1

Mirk-IN-1 (Synonyms: Dyrk1B/A-IN-1)

Cat. No.: HY-12838 Purity: 99.53%
Handling Instructions

Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively.

For research use only. We do not sell to patients.

Mirk-IN-1 Chemical Structure

Mirk-IN-1 Chemical Structure

CAS No. : 1386979-55-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 211 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 768 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively. IC50 value: 68±48/22±8 nM (Dyrk1B/Dyrk1A) [1] Target: Dyrk inhibitor Mirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by 88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2].

Molecular Weight

498.32

Formula

C₂₃H₁₇Cl₂N₅O₄

CAS No.

1386979-55-0

SMILES

ClC1=CC=C(C(NCC2=CC(Cl)=CC=C2)=O)C=C1NC(C3=CC4=CN=C(OC)N=C4N=C3O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.03 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0067 mL 10.0337 mL 20.0674 mL
5 mM 0.4013 mL 2.0067 mL 4.0135 mL
10 mM 0.2007 mL 1.0034 mL 2.0067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.5 mg/mL (1.00 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.53%

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Mirk-IN-1
Cat. No.:
HY-12838
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