2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Neuromedin N

Neuromedin N  (Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Cat. No.: HY-P0079 Purity: 99.61%
COA Handling Instructions

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neuromedin N Chemical Structure

Neuromedin N Chemical Structure

CAS No. : 92169-45-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 177 In-stock
Solution
10 mM * 1 mL in Water USD 177 In-stock
Solid
5 mg USD 108 In-stock
10 mg USD 156 In-stock
25 mg USD 336 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Neuromedin N Related Antibodies

Top Publications Citing Use of Products

    Neuromedin N purchased from MedChemExpress. Usage Cited in: Cell Signal. 2018 Dec;52:147-154.  [Abstract]

    Human PASMCs are treated with Neuromedin N (400 nM) for various durations, cell lysates are prepared and phosphorylated forms of ERK (pERK), Stat3 (pStat3), Raf-1 (pRaf-1) and MEK (pMEK) are monitored by Western blotting using pERK1/2 (T202/Y204), pStat3 (Y705), pRaf-1 (S338) and pMEK1/2 (S217/221) antibodies.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

    IC50 & Target

    Dopamine D2 receptor[1].
    In Vitro

    Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Neuromedin N Related Antibodies
    Molecular Weight

    745.95

    Appearance

    Solid

    Formula

    C38H63N7O8
    CAS No.
    Sequence

    Lys-Ile-Pro-Tyr-Ile-Leu
    Sequence Shortening

    KIPYIL
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (67.03 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3406 mL 6.7029 mL 13.4057 mL
    5 mM 0.2681 mL 1.3406 mL 2.6811 mL
    10 mM 0.1341 mL 0.6703 mL 1.3406 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (67.03 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Neuromedin N Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Neuromedin N92169-45-4Neuromedin N (rat, mouse, porcine, canine)Dopamine ReceptorInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Neuromedin N
    Cat. No.:
    HY-P0079
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.