1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Neuromedin N

Neuromedin N (Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Cat. No.: HY-P0079 Purity: 99.91%
Handling Instructions

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neuromedin N Chemical Structure

Neuromedin N Chemical Structure

CAS No. : 92169-45-4

Size Price Stock Quantity
10 mM * 1 mL in Water USD 177 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Estimated Time of Arrival: December 31
25 mg USD 336 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Neuromedin N purchased from MCE. Usage Cited in: Cell Signal. 2018 Dec;52:147-154.

    Human PASMCs are treated with Neuromedin N (400 nM) for various durations, cell lysates are prepared and phosphorylated forms of ERK (pERK), Stat3 (pStat3), Raf-1 (pRaf-1) and MEK (pMEK) are monitored by Western blotting using pERK1/2 (T202/Y204), pStat3 (Y705), pRaf-1 (S338) and pMEK1/2 (S217/221) antibodies.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

    IC50 & Target

    Dopamine D2 receptor[1].

    In Vitro

    Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

    Storage
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (67.03 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3406 mL 6.7029 mL 13.4057 mL
    5 mM 0.2681 mL 1.3406 mL 2.6811 mL
    10 mM 0.1341 mL 0.6703 mL 1.3406 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    745.95

    Formula

    C₃₈H₆₃N₇O₈

    CAS No.

    92169-45-4

    Sequence

    Lys-Ile-Pro-Tyr-Ile-Leu

    Sequence Shortening

    KIPYIL

    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Neuromedin N
    Cat. No.:
    HY-P0079
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    Neuromedin N

    Cat. No.: HY-P0079