Neuromedin N
Based on 2 publication(s) in Google Scholar
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.
For research use only. We do not sell to patients.
- Purity: 99.69%
- CAS No.: 92169-45-4
- Formula: C38H63N7O8
- Molecular Weight:745.95
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Neuromedin N
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Customer Validation & Images
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All Dopamine Receptor Isoforms
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Biological Activity
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D2 Receptor |
Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 92169-45-4
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Appearance Solid
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Molecular Weight 745.95
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Formula C38H63N7O8
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Color White to off-white
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Synonyms
Neuromedin N (rat, mouse, porcine, canine)
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Sequence
Lys-Ile-Pro-Tyr-Ile-Leu
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Sequence Shortening
KIPYIL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Metab
2021 Jul 6;33(7):1449-1465.e6. PMID: 34038712 -
Cell Signal
2018 Dec:52:147-154. PMID: 30213686
Neuromedin N purchased from MedChemExpress. Usage Cited in: Cell Signal. 2018 Dec:52:147-154. [Abstract]
Human PASMCs are treated with Neuromedin N (400 nM) for various durations, cell lysates are prepared and phosphorylated forms of ERK (pERK), Stat3 (pStat3), Raf-1 (pRaf-1) and MEK (pMEK) are monitored by Western blotting using pERK1/2 (T202/Y204), pStat3 (Y705), pRaf-1 (S338) and pMEK1/2 (S217/221) antibodies.
Solvent & Solubility
H2O : 50 mg/mL (67.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (67.03 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [Content Brief]
[2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.3406 mL | 6.7029 mL | 13.4057 mL | 33.5143 mL |
| 5 mM | 0.2681 mL | 1.3406 mL | 2.6811 mL | 6.7029 mL | |
| 10 mM | 0.1341 mL | 0.6703 mL | 1.3406 mL | 3.3514 mL | |
| 15 mM | 0.0894 mL | 0.4469 mL | 0.8937 mL | 2.2343 mL | |
| 20 mM | 0.0670 mL | 0.3351 mL | 0.6703 mL | 1.6757 mL | |
| 25 mM | 0.0536 mL | 0.2681 mL | 0.5362 mL | 1.3406 mL | |
| 30 mM | 0.0447 mL | 0.2234 mL | 0.4469 mL | 1.1171 mL | |
| 40 mM | 0.0335 mL | 0.1676 mL | 0.3351 mL | 0.8379 mL | |
| 50 mM | 0.0268 mL | 0.1341 mL | 0.2681 mL | 0.6703 mL | |
| 60 mM | 0.0223 mL | 0.1117 mL | 0.2234 mL | 0.5586 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Neuromedin N Related Classifications
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