Infection

L-Acosamine nucleoside is a furanose-configured glycoside with potential antiviral activity.

HBV-IN-47 (compound 4a) is a capsid assembly regulator with inhibitory activity against hepatitis B virus (HBV). HBV-IN-47 exhibits strong anti-HBV activity in HepAD38 cells with low toxicity (EC₅₀=0.24 μM). HBV-IN-47 can be used for the study of chronic hepatitis B (CHB).

Antiviral agent 8 with significantly higher antiviral activities than lead compounds (crocin-1 and crocin-2) emerges as a new antiviral candidate.

Isobonducellin is a flavonoid product and shows antimicrobial activity.

GF-17 is a polypeptide containing 17 amino acids. is the precursor peptide of GF19. GF-17 exhibits significant antiviral activity. GF-17 can be used for research on viral infections such as HSV-1 virus.

KLA peptide acetate is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells. KLA peptide acetate can induce cell Apoptosis by disrupting mitochondrial membranes and activating Caspase. MG1-KLA acetate, formed by the coupling of KLA peptide acetate with MG1, can selectively induce apoptosis in pro-inflammatory microglia. KLA peptide acetate can be used for the research of liver fibrosis. KLA peptide acetate can be used for the research of neonatal hypoxic-ischemic encephalopathy.

SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.

Zelkovamycin is a cyclic peptide antibiotic originally isolated from Streptomyces. It inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii in a concentration-dependent manner when used at concentrations ranging from 0.01 to 300 μg/mL.

α-Artemether is an antimalarial compound.

Pyraclostrobin (Standard) is the analytical standard of Pyraclostrobin. This product is intended for research and analytical applications. Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.

N-Myristoyl-D-asparagine-d₂ is the deuterium labeled N-Myristoyl-D-asparagine (HY-N18530). N-Myristoyl-D-asparagine is a key metabolic marker in the biosynthesis and maturation of colibactin. N-Myristoyl-D-asparagine acts as a biomarker for detecting colibactin. N-Myristoyl-D-asparagine exhibits mild growth inhibitory activity against Bacillus subtilis NCIB 3610.

Tedizolid (phosphate) (Standard) is the analytical standard of Tedizolid (phosphate). This product is intended for research and analytical applications. Tedizolid phosphate (TR-701FA) is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria[1].

Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL).

GSK572A is a potent EchA6 inhibitor with an K_d value of 1.9 µM. GSK572A shows anti-tubercular activity.

BB-83698 is a peptide deformylase (PDF) inhibitor. BB-83698 exhibits potent in vitro activity against Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) range of 0.06-0.25μg/mL. BB-83698 elevates the survival rate of mice regardless of whether the infecting strain carries resistance mechanisms. BB-83698 can be used for the study of diseases related to drug-resistant Streptococcus pneumoniae infections.

Antifungal agent 15 has the most potent activity with EC₅₀ values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC₅₀ value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections.

(2RS)-FPMPA can be used for synthesis of antiretroviral agents against HIV-1 and HIV-2.

NIP-22c is a novel coronavirus 3CL_pro inhibitor. The EC₅₀ for Verona, Calu3, Caco2 and HBTEC-ALI were 4.6, 1.1, 0.1 and 0.6 μM, respectively. NIP-22c has antiviral activity.

Tenofovir-C3-O-C15-CF3 (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo.