Infection

SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 M^pro with an IC₅₀ of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC₅₀ of 1.6 μM.

Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.

WEHI-326 is a potent antimalarial agent targeting Plasmodium falciparum ROM8 and CSC1 proteins (IC₅₀=0.006 μM). WEHI-326 is promising for research of malaria.

Helvecardin A is a glycopeptidtic antibiotic. Helvecardin A has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus.

SARS-CoV-2-IN-121 (Compound 74) is a SARS-CoV-2 virus inhibitor. SARS-CoV-2-IN-121 exhibits IC₅₀ values in the pseudovirus and live virus systems of 1.6 and 0.45 μM respectively. SARS-CoV-2-IN-121 effectively inhibits the replication or protein expression of the virus within cells and has almost no toxicity to host cells. SARS-CoV-2-IN-121 can be used for SARS-CoV-2 virus infection research.

Cervicarcin is an antitumor antibiotic with a strong inhibitory effect on sarcoma 180 and sarcoma NF, but has a weak effect on sarcoma 37, Ehrman's ascites cancer and Friend leukemia.

Influenza A virus-IN-17 (Compound 6a) is a potent influenza A inhibitor with EC₉₀s of 3.5 μM and 2.6 μM for H3N2 and H1N1, respectively. Influenza A virus-IN-17 inhibits U2-PB2 chimeric mRNA (EC₉₀ = 2.1 μM from cap snatching polymerase).

NDM-1-IN-12 (Compound 10c) is an inhibitor of NDM-1 metallo-β-lactamase, with an IC₅₀ value of 9 nM. NDM-1-IN-12 effectively reverses bacterial resistance to β-lactam antibiotics and shows an additive effect when used in combination with antibiotics and SBL inhibitors. NDM-1-IN-12 can be used in the research of anti-multi-drug resistant bacteria.

SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor. SDH-IN-33 exhibits excellent fungicidal activity with an EC₅₀ of 0.07 μg/mL. SDH-IN-33 inhibits R. solani succinate dehydrogenase (RsSDH) with an IC₅₀ 0.35 μg/mL. SDH-IN-33 can be used for the study of fungal infection.

Pipcroside C is found in P. crocatum Ruiz & Pav. Pipcroside C is a PDH inhibitor (IC₅₀: 80.25 µM). Pipcroside C has antibacterial activity and is used in the study of oral infections.

Sodium methylparaben (Standard) is the analytical standard of Sodium methylparaben. This product is intended for research and analytical applications. Sodium methylparaben (Sodium methyl 4-hydroxybenzoate) is an antifungal agent.

ACP1b is an activator for ClpP protease with K_d of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL.

Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.

UGM-IN-2 is a UGM inhibitor with a K_d of 20 μM. It binds to the UGM isoforms of K. pneumoniae (Klebsiella pneumoniae) and M. tuberculosis (Mycobacterium tuberculosis) and inhibits mycobacterial growth. UGM-IN-2 can be used in studies related to mycobacterial infections and tuberculosis.

Dioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC₅₀ of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites.

LQFM326 is an antimycobacterial agent. LQFM326 shows MIC of 15.6 μg/mL against Mycobacterium tuberculosis H37Ra and 12.5 μg/mL against clinical strains. LQFM326 can cause depressions and pores to appear on the surface of the mycobacterium causing abscesses, shortening the bacterial length, increasing its thickness, and damaging the integrity of the cell wall. LQFM326 can be used for the research of tuberculosis.

2,2-Dibromo-2-cyanoacetamide is a non-oxidizing bactericide. 2,2-Dibromo-2-cyanoacetamide enhances bactericidal activity by reacting with sulfhydryl groups on the cell walls of microorganisms in aquatic environments to release bromide ions. 2,2-Dibromo-2-cyanoacetamide effectively inactivates Legionella pneumophila, rendering it non-culturable, and exhibits significantly higher killing efficacy against this bacterium in reservoir biofilms than in aerosol biofilms. 2,2-Dibromo-2-cyanoacetamide is suitable for legionellosis prevention and control as well as related research.

Amantadine (hydrochloride) (Standard) is the analytical standard of Amantadine (hydrochloride). This product is intended for research and analytical applications. Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.

3''-Deamino-3''-hydroxykanamycin B (NK-1012-1) is a kanamycin antibiotic. 3''-Deamino-3''-hydroxykanamycin B can be produced by S. tenebrarius. 3''-Deamino-3''-hydroxykanamycin B is effective against E. coli ATCC 25922 and E. coli CCARM 1A020, with MIC values of 128 μg/mL.

Diatretyne I (Diatretyne amide) has weak anti-Gram-positive bacterial activity.