Metabolic Disease

2'-O,4'-C-Methyleneadenosine (Standard) is the analytical standard of 2'-O,4'-C-Methyleneadenosine (HY-110407). This product is intended for research and analytical applications. 2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.

1,3-Linolein-2-linolenin is an acylglycerol.

10(E)-Pentadecenol (trans-10-Pentadecen-1-ol) is an ester product.

Coumachlor is an orally active antieoagulant agent. Coumachlor is a vitamin K antagonist.

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.

Phytanic acid ethyl ester is an ester product.

1,2,3-Tri-13(Z),16(Z)-docosadienoyl-glycerol is a triacylglycerol that contains 13Z,16Z-Docosadienoic acid (HY-114610).

Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of Linoleoyl ethanolamide (HY-113421). Linoleoyl ethanolamide phosphate combined with other endogenous N-acylethanolamines plays a role in the regulation of food intake by selective prolongation of feeding latency and post-meal interval.

16:0-20:4 PG (sodium)is a phosphatidylglycerol.

1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology.

Kaempferitrin (Standard) is the analytical standard of Kaempferitrin. This product is intended for research and analytical applications. Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

MK-4074 (Standard) is the analytical standard of MK-4074 (HY-107709). This product is intended for research and analytical applications. MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

Avocadyne is an orally active mitochondrial fatty acid oxidation (FAO) inhibitor. Avocadyne induces leukemia cell death and reverses diet-induced obesity. Avocadyne inhibits fatty acid oxidation activity in leukemia cells. Avocadyne can be used in studies related to leukemia and obesity.

(R,R)-Benazepril is the R configuration of Benazepril (HY-B0093). Benazepril (CGS14824A free base) is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces the production of angiotensin II. Benazepril inhibits oxidative stress and suppresses apoptosis through the PI3K/Akt signaling pathway. Benazepril effectively ameliorates diabetic nephropathy and reduces proteinuria. Benazepril is used in the study of hypertension, heart failure, and diabetic nephropathy.

Saxagliptin-¹³C₂ (BMS-477118-¹³C₂) is ¹³C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.

C18:0 GT1b (d18:1/18:0) (triammonium) is a glycosphingolipid.

1,3-Distearoyl-2-chloropropanediol (Standard) is the analytical standard of 1,3-Distearoyl-2-chloropropanediol. This product is intended for research and analytical applications. 1,3-Distearoyl-2-chloropropanediol (2-Chloropropane-1,3-diyl distearate) is an ester product.

5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection.

13(S)-Hydroxy-9(Z),11(E)-octadecadiene-(2-biotinyl)hydrazide is an ester product.

DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.