Metabolic Disease

11β-HSD1-IN-14 (Compound 17) is a selective inhibitor for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1), with IC₅₀ of 74 nM for human HSD1, and 603 nM for HSD1 expressed HEK293 cell.

CNK-6004 is a Montirelin hydrate (NS-3) (HY-19154) metabolite.

DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

4'-Fluorouridine triphosphate (4'-F-UTP) is a monomeric raw material that can be used for nucleic acid synthesis.

Pirinixil is a hypolipidemic agent of low toxicity.

Docosyl docosanoate (Behenyl behenate) is an ester product.

DSA8 is a type II kinase inhibitor with IRE1 RNase modulating activity. DSA8 can be used for the research of cancer, metabolic disease, suah as diabetes.

Rafabegron (AJ-9677) is a specific beta3-adrenoceptor agonist. Rafabegron can reduce blood glucose, insulin, FFA, and triglyceride levels in diabetic and obese mouse models.

Pinoresinol Diglucoside (Standard) is the analytical standard of Pinoresinol Diglucoside (HY-N0657). This product is intended for research and analytical applications. Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis.

6,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

Midaglizole (Standard) is the analytical standard of Midaglizole. This product is intended for research and analytical applications. Midaglizole ((±)-DG5128 free base; DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.

Methyl 10-methylheptadecanoate is an ester product.

Peracetylated GalNAc PEG linker-azide is a monomeric raw material that can be used for nucleic acid synthesis.

Ethyl 12(Z)-heneicosenoate is an ester product.

BODIPY TMR Lyso PI ester ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

7-Keto-DHEA (Standard) (7-Oxo-DHEA (Standard)) is the analytical standard of 7-Keto-DHEA (HY-N9483). This product is intended for research and analytical applications. 7-Keto-DHEA binds to GABA Receptor, and reduces the ethanol intake in rats. 7-Keto-DHEA exhibits potential in investigation of alcohol dependence disorders.

10-Hydroxy-11(E),15(Z)-octadecadienoic acid is an ester product.

Azemiglitazone (Standard) is the analytical standard of Azemiglitazone (HY-108022). This product is intended for research and analytical applications. Azemiglitazone (MSDC-0602) is an orally active thiazolidinedione (TZD) -like molecule, which binds to PPARγ with low binding and activating affinity. Azemiglitazone inhibits mitochondrial pyruvate carrier (MPC), which inhibits Alzheimer’s disease and diminishes nonalcoholic steatohepatitis (NASH) caused liver injury.

(4Z)-4-Decenoic acid is a fatty acid.

10-Methyloctadecanoic acid is an ester product.