Neurological Disease

NocII is an orphan neuropeptide which stimulates locomotion in mice.

UCSF34 (Compound 54) is a Haloperidol (HY-14538) analogue. UCSF34 binds to the human D₂L receptor, with an estimated pK_i of 7.49. UCSF34 can be used in the research of schizophrenia.

Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively.

Ferroptosis-IN-25, Trolox (HY-101445) derivative, is a selective ferroptosis inhibitor. Ferroptosis-IN-25 selectively inhibits ferroptosis by scavenging ROS and suppressing lipid peroxidation independently of glutathion. Ferroptosis-IN-25 reduces corneal neovascularization and edema in murine corneal alkali burn models via topical administration.Ferroptosis-IN-25 can be used for the research of ocular surface diseases.

DL-Norepinephrine-d₃ hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease.

TC9-305 is a potent and selective apoptosis inhibitor. TC9-305 has strong inhibitory activity against both Bim and tBid-induced apoptosis with EC₅₀ values of 0.42 and 0.23 μM. TC9-305 can maintain the mitochondrial membrane potential, reduce ROS production, prevent the release of cytochrome c and block the upstream pathways of mitochondrial-mediated apoptosis. TC9-305 can be used for the research of neurological disease, such as storke.

Clemastine (HS-592; Meclastine) fumarate (Standard) is the analytical standard of Clemastine fumarate. This product is intended for research and analytical applications. Clemastine fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation .

AADvac 1 is an active tau peptide vaccine for Alzheimer's disease research. AADvac 1 is composed of a regulatory peptide ²⁹⁴KDNIKHVPGGGS³⁰⁵ that drives tau oligomerization conjugated to Aplysia hemocyanin (KLH) and formulated with aluminum hydroxide.

Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling.

MDL-102234 is a potent and selective adenosine A1 receptor antagonist with a K_i value of 23.2 nM at the adenosine A1 receptor. MDL-102234 can be used for the study of cognition enhancement-related neural functions.

3α-Hydroxytirucalla-7,24-dien-21-oic acid is a tirucallane triterpene isolated from the oleoresin of Protium hebetatum Daly.

CX516-d₁₀ is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

AGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults.

TGN, Cys modified is a cysteine modified TGN (HY-P11284) on the C-terminus. TGN, a 12-amino acid ligand, is a BBB-penetrating peptide. TGN can be used as a drug delivery vehicle for Alzheimer's disease research.

Tmem175 modulator 2 (example 180) is a TMEM175 modulator.Tmem175 modulator 2 can be used for the research of neurodegenerative disorders.

Shiga-Y51 is a molecular probe that can cross the blood-brain barrier and selectively bind Aβ oligomers. Shiga-Y51 can be imaged based on fluorine-19 nuclear magnetic resonance imaging (¹⁹F-MRI) technology. Shiga-Y51 exhibits extremely strong binding affinity for early to intermediate Aβ oligomers, while having almost no affinity for mature Aβ fibrils. Shiga-Y51 is a derivative of Curcumin (HY-N0005) and can inhibit the binding of Curcumin to Aβ oligomers with an IC₅₀ of 34.61 µM. Shiga-Y51 can be used in research related to Alzheimer's disease.

Caspase-6-IN-1 is a Caspase-6 inhibitor with an IC₅₀ of 5.6 μM. Caspase-6-IN-1 can inhibit Caspase-6 activity and reduce lamin A hydrolysis. Caspase-6-IN-1 can be used for the research of neurodegenerative diseases such as Huntington's disease and Alzheimer's disease.

Cy3 labled Patisiran sodium is a Cy3 labled Patisiran sodium.

MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC₅₀ of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research.

Trimipramine is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy.