2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Roflumilast Impurity E

Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a agent which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.

For research use only. We do not sell to patients.

Roflumilast Impurity E

Roflumilast Impurity E Chemical Structure

CAS No. : 1391052-76-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Roflumilast Impurity E:

Roflumilast Impurity E Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a agent which acts as a selective and long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.

Molecular Weight

349.12

Formula

C13H8Cl2F2N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8643 mL 14.3217 mL 28.6434 mL
5 mM 0.5729 mL 2.8643 mL 5.7287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8643 mL 14.3217 mL 28.6434 mL 71.6086 mL
5 mM 0.5729 mL 2.8643 mL 5.7287 mL 14.3217 mL
10 mM 0.2864 mL 1.4322 mL 2.8643 mL 7.1609 mL
15 mM 0.1910 mL 0.9548 mL 1.9096 mL 4.7739 mL
20 mM 0.1432 mL 0.7161 mL 1.4322 mL 3.5804 mL
25 mM 0.1146 mL 0.5729 mL 1.1457 mL 2.8643 mL
30 mM 0.0955 mL 0.4774 mL 0.9548 mL 2.3870 mL
40 mM 0.0716 mL 0.3580 mL 0.7161 mL 1.7902 mL
50 mM 0.0573 mL 0.2864 mL 0.5729 mL 1.4322 mL
60 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1935 mL
80 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8951 mL
100 mM 0.0286 mL 0.1432 mL 0.2864 mL 0.7161 mL
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Roflumilast Impurity E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Roflumilast Impurity E1391052-76-8Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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