1. Anti-infection
  2. HIV
    Influenza Virus
  3. Sodium copper chlorophyllin B

Sodium copper chlorophyllin B 

Cat. No.: HY-B2226
Handling Instructions

Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC50s of 50 to 100 μM for both of them.

For research use only. We do not sell to patients.

Sodium copper chlorophyllin B Chemical Structure

Sodium copper chlorophyllin B Chemical Structure

CAS No. : 28302-36-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC50s of 50 to 100 μM for both of them.

IC50 & Target

IC50: 50 to 100 μM (Influenza virus), 50 to 100 μM (HIV)[1]

In Vitro

Sodium copper chlorophyllin B exhibits influenza virus adsorption at 200 µM (P<0.05). The IC50 and the 50% cytotoxic concentration (CC50) of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively. Sodium copper chlorophyllin B also inhibits HIV adsorption at 2.5 mM (P<0.05). The IC50 and CC50 of Sodium copper chlorophyllin lay from 50 to 100 µM and 200 to 400 µM, respectively[1].

Molecular Weight

738.13

Formula

C₃₄H₂₉CuN₄Na₃O₇

CAS No.

28302-36-5

SMILES

[O-]C(CC1=C(C(C([O-])=O)=C(C)C2=CC3=[N]4C(C(C=O)=C3CC)=CC5=C(C=C)C(C)=C6[N-]75)[N-]2[Cu+2]47[N](C8=C6)=C1C(C8C)CCC([O-])=O)=O.[Na+].[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (13.55 mM; Need ultrasonic)

DMSO : 6.67 mg/mL (9.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3548 mL 6.7739 mL 13.5477 mL
5 mM 0.2710 mL 1.3548 mL 2.7095 mL
10 mM 0.1355 mL 0.6774 mL 1.3548 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.67 mg/mL (0.91 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

MT-2 cells are pre-incubated to the bamboo leaf extract solution (up to 10%), Sodium copper chlorophyllin (up to 5 mM) or test reagent-free culture medium for 10 min to assess the inhibitory activity at adsorption. The pre-incubated cells are washed extensively to be able to eliminate antiviral activity of test reagents remaining in the culture medium, and then they are exposed to HIV-1LAI (1.3×10-4 TCID50 per cell). In addition to these pre-incubated cells, control wells are prepared to evaluate growth of the cells in a virus-free condition. Then, virus-exposed and mock-exposed cells are cultured in the absence of test reagents for three days. The total viable cells are counted on day 3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Sodium copper chlorophyllin BHIVInfluenza VirusHuman immunodeficiency virusInhibitorinhibitorinhibit

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Product name:
Sodium copper chlorophyllin B
Cat. No.:
HY-B2226
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