ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
Alle ADC Payloads Isoform-spezifische Produkte anzeigen
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ADC Payloads
(218)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/
Doxorubicins (11)View all products
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Duocarmycins
(18)
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Maytansinoids
(10)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
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All Product Categories
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ADC Payloads Verwandte Produkte (371)
Verwandte Produkte (371)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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DC10SMe
0 ImagesArt. -Nr.: HY-135122CAS. Nr.: 2649727-40-0DC10SMe is a DNA alkylator, can be used in the synthesis of antibody-drug conjugate (ADC). DC10SMe exhibits IC50s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively.
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sulfo-DGN462 sodium
0 ImagesArt. -Nr.: HY-101150ACAS. Nr.: 1401203-09-5sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).
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MMAF sodium (GMP)
0 ImagesArt. -Nr.: HY-15579BGCAS. Nr.: 1799706-65-2Synonyms: Monomethylauristatin F sodium (GMP)MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.
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PNU-159682 (GMP)
0 ImagesArt. -Nr.: HY-16700GCAS. Nr.: 202350-68-3PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.
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MMAF (GMP)
0 ImagesArt. -Nr.: HY-15579GCAS. Nr.: 745017-94-1Synonyms: Monomethylauristatin F (GMP)MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.
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Exatecan hydrochloride
0 ImagesArt. -Nr.: HY-13631UCAS. Nr.: 144008-87-7Synonyms: DX-8951 hydrochlorideExatecan (DX-8951) hydrochloride is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
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ProAlk01
0 ImagesArt. -Nr.: HY-183623CAS. Nr.: 1296670-84-2ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.
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Anticancer agent 81
0 ImagesArt. -Nr.: HY-151207CAS. Nr.: 2820286-56-2Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–agent conjugate (ADC) T-PBA. T-PBA maintained its mode of target and internalization ability of Trastuzumab.
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Daunorubicin citrate
0 ImagesArt. -Nr.: HY-108876CAS. Nr.: 1884557-85-0Synonyms: Daunomycincitrate; RP 13057citrate; RubidomycincitrateDaunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
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Fmoc-Val-Lys-PAB-Exatecan
0 ImagesArt. -Nr.: HY-178257CAS. Nr.: 2901788-27-8Fmoc-Val-Lys-PAB-Exatecan is a derivative of Exatecan (DX-8951) (HY-13631). Fmoc-Val-Lys-PAB-Exatecan can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Fmoc-Val-Lys-PAB-Exatecan is often combined with CD70 mAb to form ADC drugs for the study of tumors with high CD70 expression.
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AGD-0182
0 ImagesArt. -Nr.: HY-144585CAS. Nr.: 1835700-14-5AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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10-Methoxycamptothecin (Standard)
0 ImagesArt. -Nr.: HY-N0446RCAS. Nr.: 19685-10-010-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.
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PI3K/PIKK-IN-1
0 ImagesArt. -Nr.: HY-181833CAS. Nr.: 3109464-35-6PI3K/PIKK-IN-1 is a PI3K and PIKK inhibitor that serves as a payload for antibody-drug conjugates (ADC) to prepare ADC. PI3K/PIKK-IN-1 is applicable to research related to breast cancer, multiple myeloma, Burkitt lymphoma, diffuse large B-cell lymphoma, and non-small cell lung cancer.
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Diacetyl Agrochelin
0 ImagesArt. -Nr.: HY-130996CAS. Nr.: 247115-75-9Diacetyl Agrochelin is an acetyl derivative of Agrochelin, which is produced by the fermentation of a marine Agrobacterium sp. Diacetyl Agrochelin has cytotoxic activity in tumor cell lines.
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Daunorubicin-13C,d3 TFA
0 ImagesArt. -Nr.: HY-13062ASSynonyms: Daunomycin-13C,d3 TFA); RP 13057-13C,d3 TFA; Rubidomycin-13C,d3 TFADaunorubicin-13C,d3 TFA (Daunomycin-13C,d3 TFA) is the deuterium and 13C-labeled Daunorubicin TFA. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
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seco-CBI-PBD dimer
0 ImagesArt. -Nr.: HY-171718CAS. Nr.: 550356-40-6seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc.
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10NH2-11F-Camptothecin
0 ImagesArt. -Nr.: HY-156516CAS. Nr.: 2873460-30-910NH2-11F-Camptothecin is a Camptothecin (HY-16560) analogue that serves as an ADC cytotoxin for the synthesis of antibody-drug conjugates (ADCs). 10NH2-11F-Camptothecin can inhibit tumor growth and is used in cancer research.
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Nampt-IN-10
0 ImagesArt. -Nr.: HY-W1117786CAS. Nr.: 2241015-68-7Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity.
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(R)-Methotrexate-d3
0 ImagesArt. -Nr.: HY-14519CSCAS. Nr.: 2470329-38-3(R)-Methotrexate-d3 is the deuterium labeled (R)-Methotrexate.
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TNF-α agonistic 2
0 ImagesArt. -Nr.: HY-178302CAS. Nr.: 2882900-86-7TNF-α agonistic 2 (Compound 009) is a toxic molecule. TNF-α agonistic 2 reduces the thickness of the right ear in mice. TNF-α agonistic 2 can be used as an ADC toxic molecule.
