2. Antibody-drug Conjugate/ADC Related PI3K/Akt/mTOR
  3. ADC Payload PI3K
  4. PI3K/PIKK-IN-1

PI3K/PIKK-IN-1 is a PI3K and PIKK inhibitor that serves as a payload for antibody-drug conjugates (ADC) to prepare ADC. PI3K/PIKK-IN-1 is applicable to research related to breast cancer, multiple myeloma, Burkitt lymphoma, diffuse large B-cell lymphoma, and non-small cell lung cancer.

For research use only. We do not sell to patients.

PI3K/PIKK-IN-1

PI3K/PIKK-IN-1 Chemical Structure

CAS No. : 3109464-35-6

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PI3K/PIKK-IN-1 Related Antibodies

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Description

PI3K/PIKK-IN-1 is a PI3K and PIKK inhibitor that serves as a payload for antibody-drug conjugates (ADC) to prepare ADC. PI3K/PIKK-IN-1 is applicable to research related to breast cancer, multiple myeloma, Burkitt lymphoma, diffuse large B-cell lymphoma, and non-small cell lung cancer[1].

In Vitro

PI3K/PIKK-IN-1 (Compound 1) (0.000051 μM-3 μM; 1 h) potently inhibits the kinase activity of recombinant human FRAP1 (mTOR) in vitro, with an IC50 of 3.6 nM[1].
PI3K/PIKK-IN-1 (0.046-100 nM; 1 h) potently inhibits the kinase activity of recombinant human PIK3CA/PIK3R1 (p110α/p85α) in vitro, with an IC50 of 0.5 nM[1].
PI3K/PIKK-IN-1 (0.015-250 nM; 6 d) potently inhibits the proliferation of MDA-MB-453 and MDA-MB-468 breast cancer cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/PIKK-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-453 breast cancer cell
Concentration: 0.015-250 nM
Incubation Time: 6 days
Result: Inhibited MDA-MB-453 breast cancer cell proliferation with an IC50 of 0.23 nM.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468 breast cancer cell
Concentration: 0.015-250 nM
Incubation Time: 6 days
Result: Inhibited MDA-MB-468 breast cancer cell proliferation with an IC50 of 0.39 nM.
Molecular Weight

479.55

Formula

C23H25N7O3S
CAS No.
SMILES

O=S(NC1=C(OC)N=CC(C2=CC3=C(N=CC4=CN=C(C5CC5)N43)C=C2)=C1)(N6CCNCC6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K/PIKK-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/PIKK-IN-13109464-35-6ADC PayloadPI3KADC CytotoxinPhosphoinositide 3-kinasemultiple myelomadiffuse large b-cell lymphomaPIK3CA/PIK3R1 (p110α/p85α)breast cancerMDA-MB-453HCC1954non-small cell lung cancerburkitt lymphomaFRAP1 (mTOR)MDA-MB-468Inhibitorinhibitorinhibit

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