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Cat. No.: HY-181833

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PI3K/PIKK-IN-1

PI3K/PIKK-IN-1 is a PI3K and PIKK inhibitor that serves as a payload for antibody-drug conjugates (ADC) to prepare ADC. PI3K/PIKK-IN-1 is applicable to research related to breast cancer, multiple myeloma, Burkitt lymphoma, diffuse large B-cell lymphoma, and non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 3109464-35-6
Formula: C₂₃H₂₅N₇O₃S
Molecular Weight:479.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PI3K/PIKK-IN-1 Chemical Structure

CAS No.: 3109464-35-6

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All ADC Payloads Isoforms :

All PI3K Isoforms :

In Vitro

PI3K/PIKK-IN-1 (Compound 1) (0.000051 μM-3 μM; 1 h) potently inhibits the kinase activity of recombinant human FRAP1 (mTOR) in vitro, with an IC₅₀ of 3.6 nM^[1].
PI3K/PIKK-IN-1 (0.046-100 nM; 1 h) potently inhibits the kinase activity of recombinant human PIK3CA/PIK3R1 (p110α/p85α) in vitro, with an IC₅₀ of 0.5 nM^[1].
PI3K/PIKK-IN-1 (0.015-250 nM; 6 d) potently inhibits the proliferation of MDA-MB-453 and MDA-MB-468 breast cancer cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-453 breast cancer cell
Concentration:

0.015-250 nM
Incubation Time:

6 days
Result:

Inhibited MDA-MB-453 breast cancer cell proliferation with an IC₅₀ of 0.23 nM.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB-468 breast cancer cell
Concentration:

0.015-250 nM
Incubation Time:

6 days
Result:

Inhibited MDA-MB-468 breast cancer cell proliferation with an IC₅₀ of 0.39 nM.

Chemical Information

CAS No. 3109464-35-6
Molecular Weight 479.55
Formula C₂₃H₂₅N₇O₃S
SMILES

O=S(NC1=C(OC)N=CC(C2=CC3=C(N=CC4=CN=C(C5CC5)N43)C=C2)=C1)(N6CCNCC6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang W, et al. Novel pi3k and/or pikk inhibitors, antibody-drug conjugates comprising the same and uses thereof: U.S. Patent Application 19/374,186[P]. 2026-2-19.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PI3K/PIKK-IN-1

All ADC Payloads Isoforms

All PI3K Isoforms