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ADC Payloads Related Products (218)
Related Products (218)
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10NH2-11F-Camptothecin TFA
0 ImagesCat. No.: HY-156516ACAS No.: 2873461-64-210NH2-11F-Camptothecin TFA is a Camptothecin (HY-16560) analogue that serves as an ADC cytotoxin for the synthesis of antibody-drug conjugates (ADCs). 10NH2-11F-Camptothecin TFA has anticancer effects (WO2022246576A1; compound 140).
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7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione
![7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione](https://file.medchemexpress.com/product_pic/hy-169261.gif "Click to View 7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione Product Detail")
0 ImagesCat. No.: HY-169261CAS No.: 859304-28-27-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione is a synthetic intermediate that can been used in the synthesis of the alkaloid Acronycidine.
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DM1-SMe (Standard)
0 ImagesCat. No.: HY-100128RCAS No.: 138148-68-2
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Monomethyl auristatin E intermediate-16
0 ImagesCat. No.: HY-79198CAS No.: 2380991-16-0Monomethyl auristatin E intermediate-16 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).
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TAM558 intermediate-2
0 ImagesCat. No.: HY-400688CAS No.: 2135877-76-6
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SJG-136 intermediate-2
0 ImagesCat. No.: HY-402090CAS No.: 2246368-23-8SJG-136 intermediate-2 (compound 141) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA.
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Methotrexate disodium (Standard)
0 ImagesSynonyms: Amethopterin disodium (Standard); CL14377 disodium (Standard); WR19039 disodium (Standard)Methotrexate disodium (Standard) (Amethopterin disodium (Standard); CL14377 disodium (Standard); WR19039 disodium (Standard)) is the analytical standard of Methotrexate disodium (HY-14519A). This product is intended for research and analytical applications. Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer.
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Duocarmycin TM (Standard)
0 ImagesCat. No.: HY-107769RCAS No.: 157922-77-5Synonyms: CBI-TMI (Standard)Duocarmycin TM (Standard) is the analytical standard of Duocarmycin TM (HY-107769). This product is intended for research and analytical applications. Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
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Dov-Val-Dil-OH
0 ImagesCat. No.: HY-79258CAS No.: 133120-89-5Dov-Val-Dil-OH is an ADC cytotoxin.
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SG2057 (Standard)
0 ImagesCat. No.: HY-101160RCAS No.: 260417-62-7Synonyms: DRG16 (Standard)SG2057 (Standard) is the analytical standard of SG2057 (HY-101160). This product is intended for research and analytical applications. SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent.
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Exatecan mesylate (Standard)
0 ImagesCat. No.: HY-13631ARCAS No.: 169869-90-3Synonyms: DX8951f (Standard)Exatecan mesylate (Standard) is the analytical standard of Exatecan mesylate (HY-13631A). This product is intended for research and analytical applications. Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.
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Daunorubicin-13C,d3
0 ImagesCat. No.: HY-W654130Synonyms: Daunomycin-13C,d3; RP 13057-13C,d3; Rubidomycin-13C,d3Daunorubicin-13C,d3 is 13C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
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Daunorubicin hydrochloride (Standard)
0 ImagesSynonyms: Daunomycin hydrochloride (Standard); RP 13057 hydrochloride (Standard); Rubidomycin hydrochloride (Standard)Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
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Fluticasone propionate (Standard)
0 ImagesFluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
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Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc
0 ImagesCat. No.: HY-47858CAS No.: 1599440-09-1Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is an ADC cytotoxin.
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Exatecan Intermediate 1-d2
0 ImagesCat. No.: HY-42487S1CAS No.: 3061737-78-5Exatecan Intermediate 1-d2 is the deuterium labeled Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.
