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ADC Payloads Related Products (219)
Related Products (219)
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eIF4A-IN-2
0 ImagesCat. No.: HY-176843CAS No.: 3083974-69-7eIF4A-IN-2 (Compound 93) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
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Spiro-duocarmycin
0 ImagesCat. No.: HY-160969CAS No.: 1642147-15-6Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs).
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Cryptophycin analog 1
0 ImagesCat. No.: HY-107502CAS No.: 1260431-28-4Cryptophycin analog 1 is an ADC payload. Cryptophycin analog 1 shows anticancer activity. Cryptophycin analog 1 displays cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1.
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NMS-P528
0 ImagesCat. No.: HY-156249CAS No.: 1466546-45-1NMS-P528 is a DNA minor groove alkylating agent and ADC payload. NMS-P528 undergoes intramolecular cyclization to form reactive electrophilic derivatives, which in turn induce DNA damage, cell cycle arrest, and Apoptosis. NMS-P528 shows no significant anti-tumor activity as a free payload in a HER2-negative Raji lymphoma mouse xenograft model. NMS-P528 serves as the cytotoxic payload for the antibody-drug conjugate EV20/NMS-P945. NMS-P528 can be used in research related to breast cancer, gastric cancer, colon adenocarcinoma, Burkitt's lymphoma, neuroblastoma, pancreatic cancer, prostate cancer, head and neck cancer, ovarian cancer, and melanoma.
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Exatecan analog 13
0 ImagesCat. No.: HY-13631GCAS No.: 1599439-47-0Exatecan analog 13 is a analog of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50 = 2.2 μM).
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(9R)-Exatecan
0 ImagesCat. No.: HY-13631NCAS No.: 2489613-17-2Synonyms: (9R)-DX8951f(9R)-Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
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N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine
0 ImagesCat. No.: HY-164787CAS No.: 1448364-29-1N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine (Compound 14) is a tubulin polymerization inhibitor that can be used as an ADC payload.
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T01-1-d5
0 ImagesCat. No.: HY-148185SSynonyms: KL610023-d5T01-1-d5 (KL610023-d5) is the deuterium labeled T01-1 (HY-148185). T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity.
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SN-38-13C6
0 ImagesCat. No.: HY-13704S2CAS No.: 718612-55-6Synonyms: 7-Ethyl-10-hydroxycamptothecin-13C6SN-38-13C6 (7-Ethyl-10-hydroxycamptothecin-13C6) is the 13C-labeled SN-38 (HY-13704). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).
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Paclitaxel-13C6
0 ImagesCat. No.: HY-W768912Paclitaxel-13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy.
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AXC-879
0 ImagesCat. No.: HY-148555CAS No.: 2479277-22-8AXC-879, a TLR agonist (EC50: 157.2 nM). AXC-879 is an ADC Cytotoxin and can be used for ADC synthesis.
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U-031
0 ImagesCat. No.: HY-179256CAS No.: 2980737-89-9U-031 is an anti-tumor agent. U-031 can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. U-031 is commonly used in cancer research.
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Auristatin S TFA
0 ImagesCat. No.: HY-164107APurity: 99.25%Auristatin S TFA is a potent Auristatin payload. Auristatin S TFA binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S TFA acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S TFA can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.
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7-MAD-MDCPT-d5
0 ImagesCat. No.: HY-132162S7-MAD-MDCPT-d5 is the deuterated-labeled 7-MAD-MDCPT (HY-132162). 7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
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Maytansinol (Standard)
0 ImagesCat. No.: HY-19474RCAS No.: 57103-68-1Synonyms: Ansamitocin P-0 (Standard)Maytansinol (Standard) is the analytical standard of Maytansinol. This product is intended for research and analytical applications. Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].
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Paclitaxel ceribate
0 ImagesCat. No.: HY-106146CAS No.: 186040-50-6Synonyms: Protaxel
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Mertansine-13C,d3
0 ImagesCat. No.: HY-19792SSynonyms: DM1-13C,d3; Maytansinoid DM1-13C,d3Mertansine-13C,d3 (DM1-13C,d3) is the 13C- and deuterium labeled Mertansine (HY-19792). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
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Tubulin polymerization-IN-38
0 ImagesCat. No.: HY-148193CAS No.: 1005192-31-3Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs.
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Tubulysin D
0 ImagesCat. No.: HY-N2348CAS No.: 309935-57-7Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis.
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DBCO-PEG4-GGFG-Triptolide
0 ImagesCat. No.: HY-188015CAS No.: 3086791-85-4DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs.
