-
ADC Payloads Related Products (219)
Related Products (219)
-
Agrochelin
0 ImagesCat. No.: HY-130995CAS No.: 247115-74-8Agrochelin, an alkaloid cytotoxic antibiotic, is produced by the fermentation of a marine Agrobacterium sp. Agrochelin has cytotoxic activity in tumor cell lines.
-
seco-CBI dimer
0 ImagesCat. No.: HY-185488CAS No.: 2592397-70-9seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.
-
Akt/ROCK-IN-1
0 ImagesCat. No.: HY-156796CAS No.: 2983889-44-5Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma.
-
Fmoc-PEG6-VCP-Eribulin
0 ImagesCat. No.: HY-177549CAS No.: 2841688-52-4
-
Duostatin 5-13C,d3
0 ImagesCat. No.: HY-145149SDuostatin 5-13C,d3 is the 13C-labeled Duostatin 5 (HY-145149). Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
-
Exatecan-3-amine
0 ImagesCat. No.: HY-178265CAS No.: 3035271-49-6Exatecan-3-amine is an effective exatecan derivative. Exatecan-3-amine can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. Exatecan-3-amine is often combined with CLDN6 mAb to form ADC drugs for the study of tumors with high expression of CLDN6.
-
7-MAD-MDCPT-AC-(s-cyclopropane)-d2
0 ImagesCat. No.: HY-179204SCAS No.: 2911575-77-27-MAD-MDCPT-AC-(s-cyclopropane)-d2 is the deuterium labeled 7-MAD-MDCPT-AC-(s-cyclopropane) (HY-179204). 7-MAD-MDCPT-AC-(s-cyclopropane) is a derivative of camptothecin. 7-MAD-MDCPT-AC-(s-cyclopropane) can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. 7-MAD-MDCPT-AC-(s-cyclopropane) can be used for cancer research.
-
Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid
0 ImagesCat. No.: HY-176972CAS No.: 3037777-07-1Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid (Compound 5) is a cytotoxic pyrrolobenzodiazepine (PBD) dimer derivative. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid exhibits moderate DNA alkylating activity. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid can be used as the payload of ADC, thereby demonstrating strong antigen-dependent cytotoxicity.
-
STING agonist-18 diTFA
0 ImagesCat. No.: HY-150074ACAS No.: 2138299-69-9STING agonist-18 (compound 1a) diTFA is a STING agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate.
-
thioxo-Dxd
0 ImagesCat. No.: HY-178262ACAS No.: 2806052-35-5thioxo-Dxd is a Camptothecin (HY-16560) derivative. thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression.
-
STING agonist-49
0 ImagesCat. No.: HY-179626CAS No.: 2138299-66-6STING agonist-49 (Compound 1) is a STING agonist and can be used as a payload for ADCs. STING agonist-49 can be applied in lung cancer research.
-
7-MAD-MDCPT-AC-(s-cyclopropane)
0 ImagesCat. No.: HY-179204CAS No.: 2911575-71-67-MAD-MDCPT-AC-(s-cyclopropane) is a derivative of camptothecin. 7-MAD-MDCPT-AC-(s-cyclopropane) can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. 7-MAD-MDCPT-AC-(s-cyclopropane) can be used for cancer research.
-
Muscotoxin A
0 ImagesCat. No.: HY-131058CAS No.: 1653999-47-3Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.
-
Gly-7-MAD-MDCPT hydrochloride
0 ImagesCat. No.: HY-132164APurity: 98.27%Gly-7-MAD-MDCPT (Compound 4b) hydrochloride is an anticancer agent. Gly-7-MAD-MDCPT hydrochloride is a Camptothecin (HY-16560) compound, which shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM.
-
Seco-DUBA hydrochloride
0 ImagesCat. No.: HY-132180CAS No.: 1795733-93-5Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
-
MYX1715 analog 1
0 ImagesCat. No.: HY-183263CAS No.: 3119468-32-2MYX1715 analog 1 is an analog of MYX1715 (HY-164285). MYX1715 analog 1 is an N-myristoyltransferase (NMT) inhibitor that inhibits protein myristoylation modification. MYX1715 analog 1 can be conjugated to targeting antibodies via cleavable or non-cleavable linkers for use as an ADC cytotoxin. MYX1715 analog 1 is used in the development of drugs targeting tumor-associated antigens.
-
TLR7 agonist 32
0 ImagesCat. No.: HY-167774CAS No.: 1821304-87-3TLR7 agonist 32 (payload P3), a TLR7 agonist, is an ADC payload taht can be used in the synthesis of antibody-drug-conjugates (ADCs).
-
7-MAD-MDCPT TFA
0 ImagesCat. No.: HY-132162BCAS No.: 2378428-15-87-MAD-MDCPT TFA, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
