2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. T01-1

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity.

For research use only. We do not sell to patients.

T01-1 Chemical Structure

T01-1 Chemical Structure

CAS No. : 2356229-14-4

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Based on 1 publication(s) in Google Scholar

T01-1 Related Antibodies

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Description

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].

In Vitro

T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T01-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCC1806 cells
Concentration: 0-50 nM
Incubation Time: 3 days
Result: Inhibited cell proliferation with an EC50 value of 6.7 nM.
In Vivo

T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rat (half male and half female)[1].
Dosage: 1 mg/kg
Administration: Intravenous injection; single
Result: 1.19 Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1].
IV (1 mg/kg)
Female Male
AUCLast (ng/mL•h) 437 214
Cmax (ng/mL) 838 625
MRTINF (h) 2.81 0.44
T1/2 (h) 2.78 1.97
Tmax (h) 0.08 0.08
Molecular Weight

511.59

Formula

C26H29N3O6S
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1N2C(C3=NC4=CC=CC=C4C(CCN(C(C)C)S(C)(=O)=O)=C3C2)=CC5=C1COC([C@]5(O)CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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T01-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T01-12356229-14-4ADC CytotoxinADC PayloadHCC1806camptothecin derivativecancertumourantiproliferativeInhibitorinhibitorinhibit

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HY-148185
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