2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. TAM558

TAM558 is a payload molecule used for the synthesis of OMTX705. OMTX705 is a humanized anti-fibroblast-activating protein (FAP) antibody conjugated to the cytolysin TAM470 (HY-148128), with antitumor activity.

For research use only. We do not sell to patients.

TAM558 Chemical Structure

TAM558 Chemical Structure

CAS No. : 1802499-21-3

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1 mg USD 900 In-stock
5 mg USD 2300 In-stock
10 mg USD 3690 In-stock
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Based on 1 publication(s) in Google Scholar

TAM558 Related Antibodies

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Description

TAM558 is a payload molecule used for the synthesis of OMTX705. OMTX705 is a humanized anti-fibroblast-activating protein (FAP) antibody conjugated to the cytolysin TAM470 (HY-148128), with antitumor activity[1].

IC50 & Target

FAP[1]
Molecular Weight

1603.96

Formula

C79H122N14O19S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1N(CCCC1)C)N[C@@H]([C@@H](C)CC)C(N(CCC)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(NNC(OCCOCCOCCOCCNC(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=CS2)OCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (62.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6235 mL 3.1173 mL 6.2346 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6235 mL 3.1173 mL 6.2346 mL 15.5864 mL
5 mM 0.1247 mL 0.6235 mL 1.2469 mL 3.1173 mL
10 mM 0.0623 mL 0.3117 mL 0.6235 mL 1.5586 mL
15 mM 0.0416 mL 0.2078 mL 0.4156 mL 1.0391 mL
20 mM 0.0312 mL 0.1559 mL 0.3117 mL 0.7793 mL
25 mM 0.0249 mL 0.1247 mL 0.2494 mL 0.6235 mL
30 mM 0.0208 mL 0.1039 mL 0.2078 mL 0.5195 mL
40 mM 0.0156 mL 0.0779 mL 0.1559 mL 0.3897 mL
50 mM 0.0125 mL 0.0623 mL 0.1247 mL 0.3117 mL
60 mM 0.0104 mL 0.0520 mL 0.1039 mL 0.2598 mL
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TAM558 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM5581802499-21-3TAM 558TAM-558Drug-Linker Conjugates for ADCOMTX705FAPfibroblast-activating proteinTAM470antitumorInhibitorinhibitorinhibit

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