Bacterial Inhibitor

CamA-IN-1 is a Clostridioides difficile-specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC₅₀ and K_d values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI).

Anhydrochlortetracycline hydrochloride is a degradation product of chlortetracycline (HY-B1327A). Anhydrochlortetracycline hydrochloride inhibits the growth of actinomycetes.

Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts.

Antibacterial agent 19 (compound 8) is a potent antibacterial agent. Antibacterial agent 19 has antibacterial activity against K. pneumoniae, (M-R)S. aureus and (M-R,V-R)S. aureus with MIC values of 0.022, 0.022 and 0.045 mg/mL, respectively.

ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis.

CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor.

Sulfaguanidine-¹³C₆ is the ¹³C₆ labeled Sulfaguanidine. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.

Apramycin (sulfate) (Standard) is the analytical standard of Apramycin (sulfate). This product is intended for research and analytical applications. Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic.

GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent.

Aprepitant (Standard) is the analytical standard of Aprepitant. This product is intended for research and analytical applications. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM.

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3-Hydroxy-4-methoxycinnamaldehyde (compound 2) is a cinnamaldehyde from the stem bark of Flemingia paniculata Wall. 3-Hydroxy-4-methoxycinnamaldehyde exhibits antibacterial (both Gram-positive and Gram-negative) and antifungal activities (MIC = 12.5-50 μg/mL). 3-Hydroxy-4-methoxycinnamaldehyde can be used for microbial infections research.

Maculatin 1.1 TFA is an antimicrobial peptide with an MIC against Staphylococcus aureus of 7 μM. Maculatin 1.1 TFA can perforate the bacterial membrane of Staphylococcus aureus, causing bacterial death.

Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth.

m-THPP (Tetra(3-hydroxyphenyl)porphyrin; 3-THPP) is a photosensitizer. m-THPP can weakly induce ROS production and shows antitumor and antibacterial activity. m-THPP can be used for the research of photodynamic therapy (PDT).

Cefquinome is a broad-spectrum cephem antibiotic that has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae.

Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research.

Benzoic acid lithium is an aromatic alcohol found in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid lithium inhibits bacteria and fungi and acts as a preservative.

Dapsone-¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.