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CDK Related Products (486)
Related Products (486)
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Palbociclib-d4
0 ImagesCat. No.: HY-W654305CAS No.: 1628752-63-5Synonyms: PD 0332991-d4Palbociclib-d4 is deuterium labeled Palbociclib. Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
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KGA-4066
0 ImagesCat. No.: HY-180222KGA-4066 is a novel non-ATP-competitive CDK2 inhibitor. KGA-4066 inhibits CDK2/Cyclin A2 with an IC50 value of 236.7 nM, disrupts their interaction, promots CDK2 degradation via the lysosomal pathway. KGA-4066 has anticancer activity against hepatocellular carcinoma.
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Roccellic acid
0 ImagesCat. No.: HY-N12218CAS No.: 29838-46-8Synonyms: (+)-Roccellic acid; NSC 249985Roccellic acid is a methanol extract of Roccella montagnei with cytotoxicity with an IC50 value of 71.26 μg/ml.
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CDK1/CycB1 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70653CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycB1 Recombinant Human Active Protein Kinase is an ortholog of CDK1. CDK1/cyclin B1 complexes initiates mitotic entry by phosphorylating a multitude of proteins to condense chromosomes, disrupt the nuclear envelope, and enable microtubules polymerization to attach and to segregate the chromosomes.
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CDK4/6-IN-17
0 ImagesCat. No.: HY-153704CAS No.: 2035069-96-4CDK4/6-IN-17 (compound 12) is an orally active CDK4/6 inhibitor with IC50 ranging of 10-100 nM in BE(2) cells. CDK4/6-IN-17 inhibits tumor growth in COLO205 xenograft model.
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CDC7/DBF4 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70650CDC7/DBF4 Recombinant Human Active Protein Kinaseis a protein kinase that is required for the initiation of DNA replication in eukaryotes.
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(rac)-ZK-304709
0 ImagesCat. No.: HY-19471CAS No.: 1010440-84-2(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET.
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CDK4/CycD3 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70683CDK4 has a well-established role in cell-cycle controland CDK4-cyclin complexes are commonly deregulated in tumorigenesis. CDK4/CycD3 Recombinant Human Active Protein Kinase is an ortholog of CDK4.
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CDK2-IN-49
0 ImagesCat. No.: HY-179161CDK2-IN-49 (Compound 5j) is a CDK2 inhibitor with an IC50 of 0.25 μM. CDK2-IN-49 shows potent activity against CDK7 with an IC50 of 0.14 μM. CDK2-IN-49 induces Apoptosis by raising the levels of p53 and Bax protein expression while reducing the amount of Bcl-2. CDK2-IN-49 inhibits cell division. CDK2-IN-49 can be used in the research of cancer.
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Baleraciclideg
0 ImagesCat. No.: HY-187857CAS No.: 2883700-88-5Baleraciclideg is a Cyclin-dependent kinase degrader and antineoplastic.
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CDK2/CycA2 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70670CDK2 is a cyclin-dependent kinase involved in the control of the cell cycle. CDK2/CycA2 Recombinant Human Active Protein Kinase is an ortholog of CDK2.
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EGFR/CDK2-IN-4
0 ImagesCat. No.: HY-156116EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor of EGFR and CDK-2 with IC50s of 89.6 and 165.4 nM, respectively. EGFR/CDK2-IN-4 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-4 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 2.74 μM.
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Toyocamycin (Standard)
0 ImagesCat. No.: HY-103248RCAS No.: 606-58-6Synonyms: Vengicide (Standard)DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research.
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CDK8-IN-11 hydrochloride
0 ImagesCat. No.: HY-151463A
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CLK-IN-T3N
0 ImagesCat. No.: HY-130676CAS No.: 2561494-73-1CLK-IN-T3N, the negative control of CLK-IN-T3 (HY-115470), is a chemical probe for CDC-like kinase (CLK).
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Cdk2/Cyclin Inhibitory Peptide II
0 ImagesCat. No.: HY-P3731CAS No.: 237392-85-7Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner.
