EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor of EGFR and CDK-2 with IC50s of 89.6 and 165.4 nM, respectively. EGFR/CDK2-IN-4 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-4 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 2.74 μM.
For research use only. We do not sell to patients.
- Formula: C24H16N6OS2
- Molecular Weight:468.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
IC50: 89.6 (EGFR), 165.4 nM (CDK-2)[1]
Chemical Information
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Molecular Weight 468.55
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Formula C24H16N6OS2
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SMILES
SC1=NN=C2SCC(C3=NN(C4=CC=CC=C4)C=C3C(C5=CC=C6C=CC=CC6=C5)=O)=NN21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/CDK2-IN-4 Related Classifications
HY-156116 Related Classifications
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