Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1258)
Related Products (1258)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Felodipine-d5
0 ImagesCat. No.: HY-B0309S1CAS No.: 1242281-38-4Felodipine-d5 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.
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γ-Glutamylserine TFA
0 ImagesCat. No.: HY-138119ASynonyms: γ-Glu-Ser TFAγ-Glutamylserine TFA (γ-Glu-Ser TFA) is a calcium receptor activator. γ-Glutamylserine TFA can be used for Parkinson's disease research, as well as diabetes or obesity study.
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AH-1058
0 ImagesCat. No.: HY-116500ACAS No.: 228123-15-7AH-1058 is a newly synthesized antiarrhythmic agent that exhibits significant antiarrhythmic activity by delaying premature ventricular complexes and ventricular fibrillation in experimental arrhythmia models. AH-1058 effectively inhibits both ventricular tachycardia and ventricular fibrillation in the reperfusion-induced arrhythmia model in rats. AH-1058 demonstrates potent calcium channel-blocking effects, suppressing L-type Ca2+ currents in isolated cardiomyocytes.
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Levamlodipine hydrochloride
0 ImagesCat. No.: HY-14744BCAS No.: 865430-76-8Synonyms: (S)-Amlodipine hydrochloride; Levoamlodipine hydrochlorideLevamlodipine ((S)-Amlodipine; Levoamlodipin) hydrochloride is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine hydrochloride significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine hydrochloride not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine hydrochloride exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine hydrochloride may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine hydrochloride can be used in research related to hypertension and atherosclerosis.
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A-80b
0 ImagesCat. No.: HY-117568CAS No.: 135561-94-3A-80b is a pyridazino[4,5-b]indole derivate. A 80b showsantihypertensive activity and can be used for study of Arterial hypertension.
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Diltiazem-d4-1 hydrochloride
0 ImagesCat. No.: HY-14656S4CAS No.: 2699608-24-5Synonyms: CRD-401-d4-1Diltiazem-d4-1 hydrochloride (CRD-401-d4-1) is the deuterium labeled Diltiazem hydrochloride (HY-14656). Diltiazem is an orally active L-type Ca2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.
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CALP3 TFA
0 ImagesCat. No.: HY-P1075ACALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.
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COX-2-IN-55
0 ImagesCOX-2-IN-55 (compound 1) is an orally active, Celecoxib (HY-14398)-based analog with broad-spectrum anticancer activity and weak COX-2 inhibition. COX-2-IN-55 specifically inhibits SERCA2, increases caspase-3 cleavage and DR5 levels, thereby activating GRP78 and inhibiting the development of triple-negative breast cancer (TNBC). COX-2-IN-55 can also downregulate the levels of angiogenic markers VEGF-α and IL-8, inhibiting the formation of microvessels.
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Taurolithocholic acid-d5
0 ImagesCat. No.: HY-113308SCAS No.: 1265681-64-8Taurolithocholic acid-d5 is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.
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Flavoxate-d5
0 ImagesCat. No.: HY-B0549SCAS No.: 2748541-85-5Flavoxate-d5 is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.
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S-312
0 ImagesCat. No.: HY-180334CAS No.: 120004-07-1S-312 is a calcium antagonist with a bicyclic dihydrothienopyridine structure. S-312 can relax the helical strips of various isolated rabbit arteries procontracted with high potassium depolarizaiton. S-312 competitively imhibits calcium-induced contractions in depolarized basilar and femoral arteries. S-312 increases AV nodal conduction time in Langenedorff-perfused isolated rabbit hearts. S-312 exhibits vasculoselectivity, particularly for cerebral vessel.
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A-1048400
0 ImagesCat. No.: HY-120484CAS No.: 1219624-62-0A-1048400 is an orally active and selective calcium channel inhibitor with an IC50 value of 1.4 μM for N-type channels, 1.2 μM for T-type channel. A-1048400 inhibits neurotransmitter release and reduces membrane hyperexcitability, exerting potent analgesic activity. A-1048400 is promising for research of neuropathic pain (e.g., pain induced by spinal nerve ligation and chronic constriction injury).
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FPL 62129
0 ImagesCat. No.: HY-111018CAS No.: 95445-79-7FPL 62129 is an antagonist for calcium channel. FPL 62129 reduces blood pressure and total peripheral resistance, increases the cardiac contractility and cardiac output in anarsthetised beagle model. FPL 62129 also serves as a vasodilator and a direct decelerator.
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trans-AzoTAB
0 ImagesCat. No.: HY-133240CAS No.: 1109241-72-6trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures.
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MCI-176
0 ImagesCat. No.: HY-124905CAS No.: 103315-31-7MCI-176 is a calcium antagonist. MCI-176 competitively inhibits calcium-induced constriction of coronary arteries.
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Propiverine hydrochloride (Standard)
0 ImagesCat. No.: HY-116408ARCAS No.: 54556-98-8Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
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Kurtoxin
0 ImagesCat. No.: HY-P5869Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor with a Kd of 15 nM for Cav3.1 (α1G T-type) Ca2+ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca2+ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na+ channel.
