Carbonic Anhydrase
Carbonate dehydratase
Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct carbonic anhydrase enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) were described to date. Carbonic anhydrases are involved in numerous physiological and pathological processes. Many of them are important therapeutic targets with the potential to be inhibited to treat a range of disorders including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in many physiological and pathological processes, including respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs; pH and CO2 homeostasis; electrolyte secretion in various tissues and organs; biosynthetic reactions (such as gluconeogenesis, lipogenesis, and ureagenesis); bone resorption; calcification; and tumorigenicity. α-CAs are Zn2+ metalloproteins expressed in animals, vertebrates, prokaryotes, fungi, algae, protozoa, and plants. Sixteen mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc.
Carbonic Anhydrase Isoform Specific Products
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Carbonic Anhydrase
(193)
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CA
(7)
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CA I
(67)
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CA Ⅱ
(119)
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CA IX
(106)
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CA XII
(64)
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CA VII
(1)
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CA VI
(2)
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CA VA
(2)
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CA VB
(2)
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CA XIII
(2)
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CA XIV
(2)
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All Product Categories
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Carbonic Anhydrase Inhibitors
(341)
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Carbonic Anhydrase Activators
(6)
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Carbonic Anhydrase Modulators
(4)
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Carbonic Anhydrase Degrader
(1)
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Carbonic Anhydrase Ligands
(3)
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Carbonic Anhydrase Proteins
(33)
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Carbonic Anhydrase 1 (CA1) Proteins
(1)
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Carbonic Anhydrase 2 (CA-II) Proteins
(3)
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Carbonic Anhydrase 4 (CA IV) Proteins
(3)
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Carbonic Anhydrase 12 (CA-XII) Proteins
(1)
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Carbonic Anhydrase Related Products (381)
Related Products (381)
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Recombinant Proteins (33)
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Carbonic Anhydrase Isoform Comparison
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FC14-584B
0 ImagesCat. No.: HY-157462CAS No.: 1358567-64-2FC14-584B, a dithiocarbamate, is a β-Carbonic Anhydrase inhibitor. FC14-584B inhibits the growth of trophozoites. FC14-584B can be used for the research of tuberculosis.
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4-Amino-L-phenylalanine (Standard)
0 ImagesSynonyms: H-Phe(4-NH2)-OH (Standard)4-Amino-L-phenylalanine (Standard) (H-Phe(4-NH2)-OH (Standard)) is the analytical standard of 4-Amino-L-phenylalanine (HY-W016480). This product is intended for research and analytical applications. 4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) is a metabolic intermediate and an α-carbonic anhydrase (TcCA) activator with a Ka value of 0.75 μM. 4-Amino-L-phenylalanine acts through active site cavity entrance binding and a proton shuttle mechanism to enhance the catalytic rate of CO2 hydration. 4-Amino-L-phenylalanine serves as a diamine monomer for bio-based polymer synthesis and is produced in Escherichia coli via the shikimate pathway. 4-Amino-L-phenylalanine constitutes a structural component of haptens used in immunoassay development. 4-Amino-L-phenylalanine is used for the production of Chloramphenicol (HY-B0239) and Pristinamycin I in Streptomyces venezuelae and S. pristinaespiralis, respectively. 4-Amino-L-phenylalanine is used in research related to Trypanosoma cruzi infection.
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Sulclamide
0 ImagesCat. No.: HY-W403930CAS No.: 2455-92-7Sulclamide is a sulfamoylbenzoic acid derivative with diuretic activity. Sulclamide is an inhibitor of carbonic anhydrase.
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L-645151
0 ImagesCat. No.: HY-119063CAS No.: 86394-94-7L-645151 is a carbonic anhydrase inhibitor with ocular penetration and hypotensive activity. L-645151 lowers the elevated intraocular pressure (IOP) of o-chymotripsinized (o-CT) rabbit eyes. L-645151 is promising for research of an ocular hypotensive agent.
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Thiocoumarin
0 ImagesThiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research.
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Sulthiame-d4
0 ImagesCat. No.: HY-108316SCAS No.: 1795021-05-4Sulthiame-d4 is the deuterium labeled Sultiame. Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic agent.
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Carbonic anhydrase-IN-36
0 ImagesCat. No.: HY-179127Carbonic anhydrase-IN-36 (Compound 5p) is a MtCA 3 inhibitor with a Ki of 0.07 µM against MtCA 3. Carbonic anhydrase-IN-36 inhibits the β-class enzyme MtCA 3. Carbonic anhydrase-IN-36 demonstrates potent antimycobacterial activity, with an MIC of 8 µg/mL against Mtb. Carbonic anhydrase-IN-36 retains activity against Rifampicin (HY-B0272)-resistant M. tuberculosis.
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Mafenide propionate
0 ImagesCat. No.: HY-B0614CCAS No.: 12001-72-8Mafenide propionate is a dual inhibitor of dihydropteroate synthase (Dihydropteroate synthase) and carbonic anhydrase (Carbonic anhydrase). Mafenide propionate disrupts nucleotide biosynthesis by inhibiting the de novo base synthesis pathway, thereby exerting broad-spectrum antibacterial and cytotoxic effects without inducing mutations. Mafenide propionate can be used for wound assessment and promotes the formation of healthy granulation tissue, making it suitable for scenarios such as mesh skin grafting. Mafenide propionate has been widely used in studies on diseases associated with burn wound infections, acute and chronic wounds, blast injuries, open fractures, and necrotizing fasciitis.
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Benzthiazide (Standard)
0 ImagesBenzthiazide (Standard) is the analytical standard of Benzthiazide. This product is intended for research and analytical applications. Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells.
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Methyclothiazide (Standard)
0 ImagesMethyclothiazide (Standard) is the analytical standard of Methyclothiazide. This product is intended for research and analytical applications. Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.
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(Rac)-Sezolamide
0 ImagesCat. No.: HY-106331CAS No.: 123291-07-6Synonyms: MK-927 free base; (Rac)-MK 417 free base(Rac)-Sezolamide (MK-927 (free base); (Rac)-MK 417 (free base)) is a carbonic anhydrase inhibitor (CAI) (Ki: 12.0 nM). (Rac)-Sezolamide has a topical intraocular pressure (IOP) lowering effect. (Rac)-Sezolamide can be used in glaucoma research.
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Actarit (Standard)
0 ImagesSynonyms: 4-Acetylaminophenylacetic acid (Standard); MS-932 (Standard)Actarit (Standard) is the analytical standard of Actarit. This product is intended for research and analytical applications. Actarit (4-Acetylaminophenylacetic acid) is an orally active Carbonic Anhydrase II (CAII) inhibitor with an IC50 of 422 nM. Actarit shows suppressive effects experimental autoimmune encephalomyelitis in rats. Actarit inhibits the development of type ll collagen (CII)-induced arthritis in mice by suppressing delayed-type hypersensitivity to CII. Actarit can be used for the study of Multiple Sclerosis (MS) and rheumatoid arthritis.
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Topiramate-13C
0 ImagesCat. No.: HY-B0122S1Synonyms: McN 4853-13C; RWJ 17021-13CTopiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
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Diclofenamide-13C6
0 ImagesCat. No.: HY-W778555CAS No.: 1391054-76-4Diclofenamide-13C6 is 13C-labeled Diclofenamide (HY-B0397).
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Chlorzolamide
0 ImagesChlorzolamide (CL 13580) is a carbonic anhydrase (CA) inhibitor. Chlorzolamide has an effect on the skeletal muscle of rats, which can reduce the tetanic contraction force of soleus and extensor digitorum longus and prolong the relaxation time and peak time of muscle contraction. In addition, Chlorzolamide inhibits tumor cell proliferation and has antitumor activity.
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Chlorthalidone Impurity G
0 ImagesCat. No.: HY-134043CAS No.: 16289-13-7Synonyms: Chlorthalidone EP Impurity GChlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.
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Carbonic anhydrase inhibitor 31
0 ImagesCat. No.: HY-173620Carbonic anhydrase inhibitor 31 (Compound 3F4) is a mtCA2 inhibitor (Ki: 5.2 nM). Carbonic anhydrase inhibitor 31 can be used in the research of anti-tuberculosis.
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N-Desethyl Brinzolamide oxalate
0 ImagesCat. No.: HY-137966ACAS No.: 2775292-24-3Synonyms: AL-8520 oxalateN-Desethyl Brinzolamide oxalate is a dual inhibitor of Carbonic anhydrase II and Carbonic anhydrase IV with IC50s of 1.28 and 128 nM, respectively.
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Vescalagin
0 ImagesCat. No.: HY-N19401CAS No.: 36001-47-5Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties.
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CAI/II-IN-10
0 ImagesCat. No.: HY-172103CAS No.: 3116551-74-4CAI/II-IN-10 (Compound 5d) is a human carbonic anhydrase I and II (hCA I and hCA II) inhibitor with IC< The sub>50 values are 4.32 and 3.89 nM respectively.
