Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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(E)-Methyl isoferulate
0 ImagesCat. No.: HY-N7423ACAS No.: 97966-29-5Synonyms: (E)-Isoferulic acid methyl ester(E)-Methyl isoferulate ((E)-Isoferulic acid methyl ester) is a derivative of Cinnamic acid (HY-N0610A) and NO inhibitor, with an IC50 > 100 μM against nitric oxide production. (E)-Methyl isoferulate is isolable from the solid cultures of the edible mushroom Neolentinus lepideus. (E)-Methyl isoferulate exerts mild anticancer effects against liver cancer and leukemia.
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Sebacamic acid
0 ImagesCat. No.: HY-W969553CAS No.: 6249-07-6Sebacamic acid is a bioactive compound that can be used to synthesize cell delivery carriers with antioxidant activity and cellular uptake.
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Chrysoeriol 7-O-neohesperidoside
0 ImagesCat. No.: HY-184887CAS No.: 111133-90-5Chrysoeriol 7-O-neohesperidoside is a flavonoid glycoside with cytotoxicity against cancer cells. Chrysoeriol 7-O-neohesperidoside can be used in cancer-related research such as cervical cancer and liver cancer.
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PiPT
0 ImagesCat. No.: HY-168821CAS No.: 1354632-00-0PiPT is a Tryptamine (HY-B2132) compound.
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WAY-381644
0 ImagesWAY-381644 is an active molecule.
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EAPB0202
0 ImagesCat. No.: HY-171186CAS No.: 681284-82-2
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Trypanothione
0 ImagesCat. No.: HY-148205CAS No.: 96304-42-6Trypanothione is a bis-glutathionyl derivative, found in trypanosomatids. Trypanothione shows the protection against oxidative stress.
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Ceramide 8
0 ImagesCat. No.: HY-160559CAS No.: 873802-43-8Ceramide 8 is a free 6-hydroxylated ceramide found in human skin with (2S,3R,4E,6R) stereochemical configuration. Ceramide 8 is a predominant lipid component of human epidermal stratum corneum. Ceramide 8 contributes to the skin's water barrier function that prevents body water loss.
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Org-9453 bromide
0 ImagesCat. No.: HY-106962CAS No.: 160261-34-7Org-9453 bromide is a 17β-butyrate analogue of Vecuronium bromide (HY-B0118A), short-acting non-depolarizing neuromuscular blocking agent. Org-9453 bromide relaxes muscles.
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3,4-Dimethoxy-α-pyrrolidinopropiophenone hydrochloride
0 ImagesCat. No.: HY-W725184CAS No.: 28117-93-33,4-Dimethoxy-α-pyrrolidinopropiophenone hydrochloride is a drug derivative.
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3'-O-Methyl-(-)-epicatechin gallate
0 ImagesCat. No.: HY-N19627CAS No.: 607357-35-7Synonyms: 3′-M-ECG3'-O-Methyl-(-)-epicatechin gallate (3′-M-ECG) is a methylated Catechin (HY-N0898) derivative and is an antioxidant agent. 3'-O-Methyl-(-)-epicatechin gallate reduces oxygen consumption and prevents decreases in linoleic and α-linolenic acids to protect canola oil from lipid oxidation when heated.
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Benzedrone hydrochloride
0 ImagesCat. No.: HY-129281CAS No.: 1797979-43-1Benzedrone hydrochloride is an analog of Mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety.
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Geranyl-L-Cysteine
0 ImagesCat. No.: HY-N15761CAS No.: 71050-10-7
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3',4'-Dihydroxytrimethoprim
0 ImagesCat. No.: HY-W716241CAS No.: 71525-06-93',4'-Dihydroxytrimethoprim is a Trimethoprim (HY-B0510) derivative. 3',4'-Dihydroxytrimethoprim forms via sequential O-demethylation of Trimethoprim in human liver microsomes. 3',4'-Dihydroxytrimethoprim can be used for metabolic research.
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1-(2-Fluorophenyl)piperazine hydrochloride
0 ImagesCat. No.: HY-W715044CAS No.: 76835-09-11-(2-Fluorophenyl)piperazine hydrochloride is categorized as a piperazine.
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N-Nitrosodiisobutylamine
0 ImagesCat. No.: HY-W653713CAS No.: 997-95-5N-Nitrosodiisobutylamine is an alkyl derivatives of N-nitrosodiethylamine, and does not have significant carcinogenic effect.
