Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
All Product Categories
-
Drug Derivative Inhibitors
(12)
View all products
-
Drug Derivative Agonist
(1)
View all products
-
Drug Derivative Activator
(1)
View all products
-
Drug Derivative Chemical
(1)
View all products
-
Drug Derivative Inducer
(1)
View all products
-
Drug Derivative Controls
(38)
View all products
-
Drug Derivative Substrate
(1)
View all products
-
Drug Derivative Related Products (4062)
Related Products (4062)
-
CX-659S
0 ImagesCat. No.: HY-114908CAS No.: 204980-81-4CX-659S is an orally active 5-carboxamide uracil derivative. CX-659S can effectively inhibit lipid peroxidation (IC50 = 5.9 μM). CX-659S can reduce the infiltration of neutrophils and eosinophils. CX-659S inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α. CX-659S can be used for research on inflammatory conditions.
-
Senecic acid
0 ImagesCat. No.: HY-N18340CAS No.: 13588-16-4Senecic acid (Compound 3) is a chemical constituent related to pyrrolizidine alkaloids.
-
Estradiol disulfate
0 ImagesEstradiol disulfate is an estradiol disulfate ester, belonging to sulfated steroid derivatives. Estradiol disulfate is a kynurenine transaminase inhibitor that acts by competing with pyridoxal phosphate for the binding site on the apoenzyme. Estradiol disulfate protects kynurenine apo-transaminase from inactivation associated with incubation. Estradiol disulfate can be used for research on kynurenine transaminase-related diseases.
-
Sucistil
0 ImagesCat. No.: HY-145614Sucistil is an active compound. hemoglobin sucistil (bovine) is an oxygen carrier.
-
CH-38083
0 ImagesCat. No.: HY-113713CAS No.: 104786-63-2CH-38083 is an active compound.
-
Albafuran C
0 ImagesCat. No.: HY-N11577CAS No.: 84323-16-0Albafuran C is a natural phenolic compound.
-
Anhydrolutein II
0 ImagesCat. No.: HY-N15680CAS No.: 92760-19-5
-
CKS-17 (dimer)
0 ImagesCat. No.: HY-P3051ACAS No.: 162873-95-2CKS-17 (dimer) is the dimer of CKS-17 (HY-P3051). CKS-17 (dimer) can be prepared by introducing a naturally occurring cysteine at the carboxyl terminus and dimerizing via a cysteine-disulfide bond. CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has a highly conserved amino acid sequence present in the transmembrane envelope proteins of numerous animal and human retroviruses. As an immunomodulatory epitope, CKS-17 exhibits inhibitory properties on a variety of immune functions.
-
Myrianthic acid 3,23-acetonide
0 ImagesCat. No.: HY-N9132CAS No.: 578710-52-8Myrianthic acid 3,23-acetonide is a natural triterpene.
-
N-Ethyl Tadalafil
0 ImagesN-Ethyl Tadalafil is an active compound.
-
ATSP-7342
0 ImagesCat. No.: HY-P11635CAS No.: 1451198-97-2ATSP-7342 is a negative control analog of ATSP-7041. ATSP-7342 exhibits lower binding affinity to both MDM2 (Ki = 536 nM) and MDMX (Ki >1000 nM), compared with ATSP-7041.
-
Ethaverine hydrochloride (Standard)
0 ImagesEthaverine hydrochloride (Standard) is the analytical standard of Ethaverine hydrochloride (HY-B1440). This product is intended for research and analytical applications. Ethaverine hydrochloride is a Papaverine derivative and vasodilator. Ethaverine hydrochloride inhibits Phosphodiesterase, Tyrosine hydroxylase, and MAO-B. Ethaverine hydrochloride blocks L-type Ca2+ channels, reduces intracellular Ca2+ levels, inhibits platelet adhesion and aggregation, regulates cardiac conduction and heart rate, and increases peripheral and cerebral blood flow. Ethaverine hydrochloride alters cochlear microcirculation, intracochlear Po2, CM potential, and EP in guinea pigs, and induces transient hypotension. Ethaverine hydrochloride is used in the research of peripheral vascular diseases.
-
(±)10(11)-EDP ethanolamide
0 ImagesCat. No.: HY-138969CAS No.: 2123484-71-7Synonyms: 10,11-EDP-EA; 10,11-EDP epoxide; 10,11-Epoxy docosapentaenoic ethanolamide(±)10(11)-EDP ethanolamide (10,11-EDP-EA) (compound C) is an ω-3 endocannabinoid epoxide derivative with antiangiogenic, antitumor and anti-migratory properties in osteosarcoma models.
-
BTG-1675A
0 ImagesCat. No.: HY-108071CAS No.: 812639-72-8BTG-1675A is a isoxazoline compound with anxiolytic property. BTG-1675A can be used for the research of anxiety.
-
Cascaroside F
0 ImagesCat. No.: HY-N21607CAS No.: 164322-83-2Cascaroside F is an O,C-diglucosyl anthrone natural product found in the bark of Rhamnus purshiana, belonging to the emodin series of 10-C-β-D-glucopyranosyl-9-anthrones.
-
Antitumor agent-66
0 ImagesCat. No.: HY-147540CAS No.: 2456288-81-4Antitumor agent-66 (Compound 4) is an analogue/derivative of (-)-cleistenolide. Antitumor agent-66 has the potential for the research of cancer diseases.
-
Bucloxic acid calcium
0 ImagesCat. No.: HY-101581ACAS No.: 32808-53-0Synonyms: 804 CB calcium; Bucloxonic acid calcium; Esfar calciumBucloxic acid calcium is an anti-inflammatory pyrrazole derivative. Bucloxic acid calcium can be used for study of chronic glomerular nephropathies.
-
N-Cholyl-L-aspartic acid
0 ImagesCat. No.: HY-176968CAS No.: 18416-55-2Synonyms: AspCAN-Cholyl-L-aspartic acid (AspCA) is a N-cholyl Amino Acid (HY-168761) derivative. N-Cholyl-L-aspartic acid can be used for the study of inflammatory bowel disease (IBD).
