Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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VHB937 (IgG1-LALA)
0 ImagesCat. No.: HY-P991734AVHB937 (IgG1-LALA) is a derivative of VHB937 (HY-P991734). VHB937 is a human monoclonal antibody that acts as a potent and selective TREM2 agonist. VHB937 enhances the surface expression of TREM2 and its downstream signaling pathways, such as Syk phosphorylation and calcium mobilization. VHB937 has demonstrated significant neuroprotective effects in various animal models of neuroinflammation and neurodegeneration, effectively alleviating pathological damage and reducing pro-inflammatory marker levels. VHB937 can be used in research related to neurodegenerative diseases.
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RJ-34
0 ImagesCat. No.: HY-144872CAS No.: 1170694-29-7RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI50 values in the subnanomolar range (GI50 <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells).
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Apoptone
0 ImagesCat. No.: HY-16247CAS No.: 183387-50-0Synonyms: HE3235Apoptone (HE3235) is an orally active 3β-androstanediol analog. Apoptone reduces the expression of androgen receptor (Androgen receptor) and decreases intratumoral androgen levels. Apoptone exhibits anticancer activity against castration-resistant prostate cancer.
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Butikacin
0 ImagesCat. No.: HY-187726CAS No.: 59733-86-7Synonyms: UK-18892
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Mito-Esculetin
0 ImagesCat. No.: HY-184265CAS No.: 1993461-76-9Synonyms: Mito-EscMito-Esculetin (Mito-Esc) is an orally active mitochondria-targeted derivative of Esculetin (HY-N0284). Mito-Esculetin inhibits LPS-induced phosphorylation of STAT3 Tyr-705, partially reverses LPS-mediated depletion of SIRT3, and enhances the AMPK-SIRT1 signaling axis. Mito-Esculetin inhibits PAI-1 activity, regulates miRNA, and induces phosphorylation of IRS and AKT. Mito-Esculetin suppresses oxidant-induced endothelial dysfunction, Ang-II (HY-13948)- and high glucose-induced atherosclerotic plaque formation, Palmitate (HY-N0830)-induced insulin resistance, as well as high glucose-mediated endothelial cell senescence and inflammatory responses. Mito-Esculetin reduces body weight and non-esterified fatty acid (NEFA) levels. Mito-Esculetin can be used in research related to acute coronary syndrome, type 2 diabetes, and hyperglycemia-induced atherosclerosis.
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(S)-(-)-Propranolol
0 Images(S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain.
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Acetildenafil-d8
0 ImagesCat. No.: HY-13927SCAS No.: 1189944-10-2Acetildenafil-d8 is the deuterium labeled Acetildenafil. Acetildenafil is a structural analog of Sildenafil (HY-15025). Sildenafil is a phosphodiesterase-5 (PDE-5) inhibitor.
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Desethylene Ciprofloxacin-d4 hydrochloride
0 ImagesCat. No.: HY-141789SCAS No.: 1330261-13-6Desethylene Ciprofloxacin-d4 hydrochloride is the deuterated-labeled Desethylene Ciprofloxacin hydrochloride (HY-122139). Desethylene Ciprofloxacin hydrochloride is a major metabolite and degradation product of Ciprofloxacin (HY-B0356). Desethylene Ciprofloxacin hydrochloride inhibits topoisomerase (Topoisomerase) IIα and IIβ-mediated DNA relaxation.
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4-Tolyl-sulfonamide-d4
0 ImagesCat. No.: HY-79602SCAS No.: 1219795-34-2Synonyms: p-Tosylamide-d44-Tolyl-d4-sulfonamide (p-Tosylamide-d4) is the d4-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research.
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3,6-Dihydroxy-1,7-dimethoxyxanthone
0 ImagesCat. No.: HY-N9034CAS No.: 262292-34-23,6-Dihydroxy-1,7-dimethoxyxanthone is a natural xanthone.
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Sibiriquinone B
0 ImagesCat. No.: HY-N16822CAS No.: 723300-09-2Sibiriquinone B is a natural other quinones.
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4-BEC hydrochloride
0 ImagesCat. No.: HY-118687CAS No.: 135333-26-54-Bromoethcathinone hydrochloride is structurally categorized as a drug derivative.
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Escin IVc
0 ImagesCat. No.: HY-N16687CAS No.: 249921-71-9Escin IVc is a natural triterpene.
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13-Hydroxylabda-8(17),14-dien-18-oic acid
0 ImagesCat. No.: HY-N16906CAS No.: 83915-59-713-Hydroxylabda-8(17),14-dien-18-oic acid is a natural diterpene.
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GV196771
0 ImagesCat. No.: HY-117906CAS No.: 166974-22-7GV196771 is an active compound.
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Vitamin K2(5)
0 ImagesVitamin K2(5) is an isoprenyl homologue of the Vitamin K2 (HY-109569) series. Vitamin K2(5) occurs in the heartwood of Tabebuia avellanedae.
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Prostaglandin A1-biotin
0 ImagesCat. No.: HY-113053FSynonyms: PGA1-biotinProstaglandin A1-biotin (PGA1-biotin) is a biotin-labeled Prostaglandin A1 (HY-113053). Prostaglandin A1-biotin can be found in the culture filtrate of rhizobia, and the culture filtrate containing this compound exhibits significant antiviral activity.
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(Rac)-L-826141
0 ImagesCat. No.: HY-117558CAS No.: 491869-01-3(Rac)-L-826141 is an active compound.
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4α-Hydroxybisabola-2,10-diene-1,9-dione
0 ImagesCat. No.: HY-N17023CAS No.: 1627567-79-64α-Hydroxybisabola-2,10-diene-1,9-dione is a natural sesquiterpene.
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1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
0 ImagesCat. No.: HY-N10158CAS No.: 207792-17-41,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells.
