Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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2-Chloro-1,3-propanediol
0 ImagesSynonyms: 2-MCPD2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis.
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α-D-Glucose-1-phosphate
0 ImagesCat. No.: HY-W400427CAS No.: 59-56-3α-D-Glucose-1-phosphate is a derivative of D-glucose (HY-B0389). α-D-Glucose-1-phosphate serves as a starting material for glucuronic acid synthesis. Glucuronic acid acts as a Ca2+ chelator and also functions as a biosynthetic substrate for the production of linear maltooligosaccharides or α,α-trehalose. α-D-Glucose-1-phosphate can be used as a cytostatic compound, Antibiotic, and immunosuppressant essential for heart disease management. α-D-Glucose-1-phosphate is applicable to the research of heart disease.
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1-Linolenoyl-3-chloropropanediol
0 Images1-Linolenoyl-3-chloropropanediol is an ester product.
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8-Oxogeranial
0 Images8-Oxogeranial is a monoterpene. The terpenoid is produced by 8-hydroxygeraniol dehydrogenase which uses 8-hydroxygeraniol as its substrate. 8-Oxogeranial is itself a substrate for iridoid synthase which synthesizes cis-trans-iridodial and cis-trans-nepetalactol.
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4-Propylcatechol
0 Images4-Propylcatechol is an Allylpyrocatechol (HY-124127) analog. 4-Propylcatechol shows anti-malarial activity against Plasmodium falciparum CDC-1 with an IC50 of 32 µM.
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Bacampicillin
0 ImagesCat. No.: HY-B1149CAS No.: 50972-17-3Bacampicillin is an orally active semi-synthetic aminopenicillin derivative, prodrug and bactericide that is readily inactivated by β-lactamases. Bacampicillin is hydrolyzed by carboxylester hydrolases and non-specific esterases in the gastrointestinal wall and plasma to form Ampicillin (HY-B0522), and produces higher levels of Ampicillin in rodents in vivo. Bacampicillin exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Bacampicillin can be used in studies related to bacterial infections.
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Loxoprofen L-menthol ester
0 ImagesLoxoprofen L-menthol ester is a degradation product Loxoprofen sodium (HY-B0578A). Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties.
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Triacontane
0 ImagesTriacontane is an ester product.
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WAY-358981
0 ImagesCat. No.: HY-48239CAS No.: 307322-32-3WAY-358981 is an active molecule.
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Dasatinib derivative 1
0 ImagesDasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma.
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Methyl-4-oxoretinoate
0 ImagesMethyl-4-oxoretinoate is a derivative of Retinoic acid (HY-14649). Methyl-4-oxoretinoate inhibits TPA (HY-18739)-induced ornithine decarboxylase (ODC) activity, and carcinogen-induced papillomas in mouse skin.
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(R)-Methyl 3-hydroxytetradecanoate
0 Images(R)-Methyl 3-hydroxytetradecanoate is an ester product.
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3,7,25-Trihydroxycucurbita-5,23-dien-19-al
0 ImagesCat. No.: HY-N10685CAS No.: 85372-65-2Synonyms: TCD3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida.
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Daunorubicin-Cytarabine Liposome
0 ImagesCat. No.: HY-160952CAS No.: 1256639-86-7Synonyms: CPX 351; Cytarabine-daunorubicinCytarabine-daunorubicin (CPX 351) is a Liposomal formulation prepared from Cytarabine (HY-13605) and Daunorubicin (HY-13062A) at a fixed synergistic molar ratio of 5:1. Cytarabine-daunorubicin improves secondary acute myeloid leukemia. Cytarabine-daunorubicin can be used in research related to secondary acute myeloid leukemia, high-risk myelodysplastic syndrome, and chronic myelomonocytic leukemia.
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Silatecan
0 ImagesCat. No.: HY-16055CAS No.: 220913-32-6Synonyms: AR-67; DB 67Silatecan (AR-67) is a blood-brain barrier-permeable derivative of Camptothecin (HY-16560), DNA topoisomerase I inhibitor, an anticancer agent, and a radiosensitizer. Silatecan potently radiosensitizes wild-type p53 gliomas. Silatecan can be used in research related to glioma, leukemia, non-small cell lung cancer, colon cancer, ovarian cancer, renal cancer, prostate cancer, breast cancer, cervical cancer, gastric cancer, nasopharyngeal cancer, and uterine cancer.
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Doxorubicinone (Standard)
0 ImagesCat. No.: HY-121309RCAS No.: 24385-10-2Synonyms: Adriamycin aglycone (Standard); Adriamycinone (Standard)Doxorubicinone (Adriamycin aglycone) (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research.
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(E)-m-Coumaric acid (Standard)
0 ImagesSynonyms: trans-3-Hydroxycinnamic acid (Standard)(E)-m-Coumaric acid (Standard) (trans-3-Hydroxycinnamic acid (Standard)) is the analytical standard of (E)-m-Coumaric acid (HY-N7127). This product is intended for research and analytical applications. (E)-m-Coumaric acid (trans-3-Hydroxycinnamic acid) is a natural phenolic cinnamic acid derivative with antioxidant activity, and it is found in the young shoots of Limonium densiflorum. (E)-m-Coumaric acid upregulates the levels of SOD and GSH and reduces MDA levels, thereby alleviating oxidative stress and lipid peroxidation in liver tissue. (E)-m-Coumaric acid can be used in studies related to oxidative stress-mediated liver injury.
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Emitefur
0 ImagesCat. No.: HY-119108CAS No.: 110690-43-2Synonyms: BOF-A2Emitefur is an orally active and potent anticancer drug. Emitefur can be used for advanced gastric cancer patients.
